Urapidil hydrochloride
Synonym(s):6-[[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride
- CAS NO.：64887-14-5
- Empirical Formula: C20H30ClN5O3
- Molecular Weight: 423.94
- MDL number: MFCD00078601
- EINECS: 636-348-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-15 13:17:26
What is Urapidil hydrochloride?
Description
Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.
The Uses of Urapidil hydrochloride
a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive
What are the applications of Application
Urapidil HCl is an adrenergic α1-AR antagonist and a serotonin 5-HT1A (SR-1A) receptor agonist
Properties of Urapidil hydrochloride
| Melting point: | 156-1580C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: soluble |
| form | solid |
| color | white |
| Water Solubility | Soluble to 50 mM in water |
Safety information for Urapidil hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Urapidil hydrochloride
Abamectin manufacturer
Alfa Omega Pharma
Biophore India Pharmaceuticals Pvt Ltd
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