Urea

Description

Urea is a stable highly water-soluble compound of high nitrogen content (47%), with good storage properties that make it the most commonly used nitrogen fertilizer. The synthesis process has remained essentially unchanged since it was first developed by the BASF Corporation in 1922. In this process, liquid ammonia is reacted with carbon dioxide to produce ammonium carbamate, which is then dehydrated to form urea. The reactions are:
2NH3 + CO2 ===? NH2·CO2·NH4
NH2·CO2·NH4 ===? (NH2)2CO + H2O

Description

Urea, also known as carbamide, is a safe, useful compound with a significant history. It is a naturally occurring molecule that is produced by protein metabolism and found abundantly in mammalian urine.
In 1828, the German chemist Friedrich W?hler1, then at the Polytechnic School (now Technical University) of Berlin, published a seminal article in which he demonstrated that a biomolecule, urea, can be synthesized from a nonbiological starting material. W?hler prepared the inorganic compound ammonium cyanate in the lab, then heated it, causing it to isomerize to urea. Now known as the “W?hler synthesis”, the reaction helped to disprove the concept of vitalism, which held that “organic” molecules can be made only by living organisms.2
In a reaction similar to the W?hler synthesis, ammonium carbamate can be converted to urea and water. This is the basis of the process that has been used to produce urea industrially for almost a century. Ammonia and carbon dioxide (CO2) react exothermically to produce the carbamate salt, which is then heated to form urea. The heat produced in the first reaction drives the second. Typically, ammonia and urea are manufactured in the same plant so that some of the carbon dioxide byproduct from ammonia production can be used to make urea.
Global urea production capacity is ≈220 million t/year. Why is urea produced in such large quantities? The answer is that, other than ammonia, urea has the highest nitrogen content of all industrial chemicals and is in high demand as a fertilizer. In the soil, it decomposes back to ammonia (actually ammonium ion) and carbon dioxide. Nitrogen-fixing bacteria oxidize ammonium to nitrate, which is readily taken up by the roots of crops. In addition to its high nitrogen content, urea is particularly useful because it can be applied as a solid in pellet form; and its unusually high solubility in water allows it to be incorporated into solutions with other plant nutrients.
More than 90% of urea production goes into agriculture. The remaining ≈20 million t made annually goes into animal feed (cattle, among others, can convert it into protein), urea–formaldehyde resins, emollients for skin care, and barbituric acid manufacture. Urea’s strongly negative heat of solution in water is the basis of instant-cold packs, in which plastic pouches contain urea and water in separate compartments. When the seal between them is broken, intermixing produces short-term cooling for aching joints and muscles.
There’s always room for improvement. In a 2018 article, ?British scientific writer David Bradley described ways in which urea might be used more efficiently in agriculture. And last year, in what might be termed a “urea revolution”, Shuangyin Wang and colleagues at Hunan University (Changsha, China) and other institutions described an electrochemical route to urea.
Although urea is used widely in agriculture, current urea production is decidedly not “green”. Ammonia and urea production consume >2% of the world’s energy and emit more CO2 than any other industrial process. Wang’s group developed an electrochemical method that skips ammonia and directly converts nitrogen gas, CO2, and water to urea at ambient temperature and pressure. The synthetic route is complex, and the process is not yet efficient or sufficiently productive, but the objective is certainly well worth striving toward.
1. W?hler was truly a pioneering chemist. In addition to his urea synthesis, he isolated the elements beryllium and yttrium in pure form, synthesized several then-unknown inorganic compounds, and introduced the concept of organic functional groups
2. After his discovery, W?hler wrote, “I can no longer hold my chemical water. I must tell you that I can make urea without the use of kidneys of any animal, be it man or dog.”

The Uses of Urea

Urea is a physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diu retic.

What are the applications of Application

Urea, 2M is stock solution used routinely as a cleaning and regeneration buffer for affinity columns

Indications

Urea is used topically for debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis, keratoderma, corns and calluses, as well as damaged, devitalized and ingrown nails.

Background

A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

What are the applications of Application

Urea is used to denature proteins or in polyacrylamide gels to fractionate low molecular weight DNA or RNA

Pharmacokinetics

Urea is a keratolytic emollient that works to treat or prevent dry, rough, scaly, itchy skin.

Metabolism

Not Available