UNC 0631
- CAS NO.:1320288-19-4
- Empirical Formula: C37H61N7O2
- Molecular Weight: 635.93
- MDL number: MFCD22683862
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is UNC 0631?
The Uses of UNC 0631
UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.[Cayman Chemical]
The Uses of UNC 0631
N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine, is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP.
What are the applications of Application
UNC0631 is a selective histone lysine methyltransferase (HMTase) inhibitor
Biological Activity
unc 0631 is a potent inhibitor of protein lysine methyltransferase g9a (also known as kmt1c or ehmt2) with the ic50 value of 4nm [1].unc 0631 has been revealed to inhibit the g9a in sahh-coupled with the ic50 of 4nm. besides, unc 0631 has been found to be highly potent in reducing h3k9me2 levels in mda-mb-231 cells with the icw ic50 of 25nm. in addition, unc 0631 has been shown the high in vitro potency against g9a and improved lipophilicity. besides, unc 0631 has also been reported to have low cell toxicity in mda-mb-231 cells with the ic50 value of 2.8μm in mtt assay. in different cell lines, unc 0631 has been demonstrated to potently reduce h3k9me2 levels with the icw ic50 of 25nm, 18nm, 26nm, 24nm, 51nm, 72nm and 46nm in mda-mb-231, mcf7, pc3, 22rv1, hct116 wt, hct 116 p53 and imr90 cell lines, respectively [1].
References
[1] liu f1, barsyte-lovejoy d, allali-hassani a, he y, herold jm, chen x, yates cm, frye sv, brown pj, huang j, vedadi m, arrowsmith ch, jin j.optimization of cellular activity of g9a inhibitors 7-aminoalkoxy-quinazolines. j med chem. 2011 sep 8;54( 17):6139-50.
Properties of UNC 0631
Boiling point: | 763.4±70.0 °C(Predicted) |
Density | 1.114±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | insoluble in H2O; ≥12.66 mg/mL in EtOH with ultrasonic; ≥18.35 mg/mL in DMSO with gentle warming |
form | solid |
pka | 9.34±0.70(Predicted) |
color | Light yellow to yellow |
Safety information for UNC 0631
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for UNC 0631
New Products
Tubulysin E (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin D Tubulysin C 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropanol Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2H-Pyran, 4-ethynyltetrahydro- Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (S)-4-(azidomethyl) -3-(3-fluoro-4- thiomorpholino phenyl) oxazolidin-2-one 2,3-dichloro-6- nitrobenzonitrile Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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