TYRPHOSTIN B48
- CAS NO.:133550-35-3
- Empirical Formula: C16H12N2O3
- Molecular Weight: 280.28
- MDL number: MFCD00209863
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:35
What is TYRPHOSTIN B48?
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
What are the applications of Application
AG 494 is a potent and selective inhibitor of EGFR tyrosine kinase
Biological Activity
Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).
References
[1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.
Properties of TYRPHOSTIN B48
Melting point: | 249 °C(dec.) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | DMSO: soluble |
form | Yellow solid. |
color | Light yellow to Amber to Dark green |
Safety information for TYRPHOSTIN B48
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for TYRPHOSTIN B48
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