TYRAMINE HYDROCHLORIDE
Synonym(s):2-(4-Hydroxyphenyl)ethylammonium chloride;4-(2-Aminoethyl)phenol hydrochloride, Tyramine hydrochloride;fMLP;Formyl-Met-Leu-Phe-OH - CAS 59880-97-6 - Calbiochem
- CAS NO.：59880-97-6
- Empirical Formula: C21H31N3O5S
- Molecular Weight: 437.55
- MDL number: MFCD00036780
- EINECS: 200-462-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-27 11:49:37
What is TYRAMINE HYDROCHLORIDE?
The Uses of TYRAMINE HYDROCHLORIDE
Induces leucocyte chemotaxis, and activates macrophages
The Uses of TYRAMINE HYDROCHLORIDE
N-Formyl-Met-Leu-Phe has been used for:
- creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils
- use in neutrophil chemotaix assay and
- determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.
What are the applications of Application
N-Formyl-Met-Leu-Phe is an inducer of superoxide release and agonist for FPR1
Definition
ChEBI: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.
General Description
N-Formyl-Met-Leu-Phe is a chemotactin peptide, which functions on polymorphonuclear leukocytes (PMN), neutrophils etc.
Biochem/physiol Actions
Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
storage
Store at -20°C
Properties of TYRAMINE HYDROCHLORIDE
| Melting point: | 271-274 °C(lit.) |
| Boiling point: | 269 °C |
| Density | 1.198±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 50 mg/mL, clear, colorless |
| form | White to off-white lyophilized solid |
| pka | 3.50±0.10(Predicted) |
| color | White to Almost white |
| BRN | 2315783 |
| CAS DataBase Reference | 59880-97-6(CAS DataBase Reference) |
Safety information for TYRAMINE HYDROCHLORIDE
Computed Descriptors for TYRAMINE HYDROCHLORIDE
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