TYROSINASE

Synonym(s):Catechol Oxidase;Monophenol Monooxygenase;Monophenol, dihydroxyphenylalanine:oxygen oxidoreductase;Polyphenol Oxidase

CAS NO.：9002-10-2
Empirical Formula: NULL
Molecular Weight: 0
MDL number: MFCD00082118
EINECS: 232-653-4
Update Date: 2024-11-19 23:02:33

What is TYROSINASE?

The Uses of TYROSINASE

Tyrosinase activity has been assessed in a study that developed an alternative therapeutic agent for treating hyperpigmentation. Tyrosinase has also been used in a study to investigate the oculocutaneous albinism phenotype in the Pakistani population.

General Description

Isoelectric point (pI): 4.7-5
pH optimum is 6-7

Molecular weight: 128 kDa by sedimentation velocity diffusion; 133?kDa by light-scattering measurements, and 119.5 kDa by electrophoresis.

Tyrosinase is a copper-containing oxidase, which has activity for both catechols and cresol. It is responsible for browning reactions. The enzyme is reported to have two binding sites for aromatic substrates and a different binding site for oxygen-copper. The copper is probably Cu(I), with inactivation involving oxidation to Cu(II) ion.

Biochem/physiol Actions

Converts tyrosine to L-DOPA or tyramine to dopamine

Properties of TYROSINASE

Melting point:	89-94 °C
storage temp.	-20°C
form	lyophilized powder
color	Light brown to brown
CAS DataBase Reference	9002-10-2
EPA Substance Registry System	Oxygenase, monophenol mono- (9002-10-2)

Safety information for TYROSINASE

Signal word	Danger
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H334:Sensitisation, respiratory
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P284:Wear respiratory protection. P501:Dispose of contents/container to..…