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HomeProduct name listTW-37

TW-37

TW-37 Structural

What is TW-37?

Description

TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively). It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells. TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously. It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.

The Uses of TW-37

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

The Uses of TW-37

TW-37 is a Bcl-2 inhibitor that suppresses growth and enhance cisplatin-induced apoptosis in ovarian cancer cells. Also functions as an MCL-1 inhibitor that kills many more malignant cells.

What are the applications of Application

TW-37 is a Bcl-2 inhibitor that inhibits the angiogenesis of endothelial cells

Definition

ChEBI: N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide is a member of benzamides.

Properties of TW-37

Boiling point: 723.7±60.0 °C(Predicted)
Density  1.280
storage temp.  Store at -20°C
solubility  insoluble in H2O; ≥19.75 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with gentle warming and ultrasonic
pka 7.86±0.50(Predicted)
form  A crystalline solid
color  White to off-white

Safety information for TW-37

Computed Descriptors for TW-37

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