TTK21

CAS NO.：709676-56-2
Empirical Formula: C17H15ClF3NO2
Molecular Weight: 357.75
MDL number: MFCD34565070
Update Date: 2024-11-19 20:33:22

What is TTK21?

Description

TTK21 is an activator of CBP/p300 histone acetyltransferase activity. It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 μM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in adult mice's subgranular zone of the dentate gyrus. It increases memory duration in the Morris water maze, with mice spending more time in the platform quadrant than untreated mice up to 16 days after learning.

The Uses of TTK21

N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide was used in preparation of benzamide compounds as modulators of enzymes histone acetyltransferases and chromatin transcription.

Properties of TTK21

Boiling point:	369.8±42.0 °C(Predicted)
Density	1.321±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml
form	A crystalline solid
pka	12.22±0.70(Predicted)
color	White to off-white
InChI	InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)