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HomeProduct name listTTP 22

TTP 22

TTP 22 Structural

What is TTP 22?

The Uses of TTP 22

TTP 22 is a CK2 inhibitor.

What are the applications of Application

TTP 22 is a casein kinase 2 (CK2) inhibitor

Biological Activity

ttp 22 is a high affinity, atp-competitive casein kinase 2 (ck2) inhibitor.casein kinase 2 (ck2) noticeably stands out against a background of the kinase family due to its constitutive catalytic activity with the ability to phosphorylate more than 300 physiological substrates. these features make ck2 appear greatly diverse points of cell signaling pathways and be involved in processes leading to the development of various disorders, especially cancer. thus, currently ck2 is regarded as druggable protein kinase target and can be used for the development of antitumor, anti-inflammatory and antiviral drugs.

in vitro

kinetic studies of ttp 22 showed that activity of (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids moiety was a result of its competition with atp molecule for the binding site. inhibition constant (ki) for ttp 22 was 40 nm. initial in vitro tests of ttp 22 and it analog on four serine/threonine (ask1, jnk3, aurora a and rock 1) and three tyrosine protein kinases (fgfr1, met and tie2) revealed their remarkable specificity towards ck2 [1].

storage

Store at +4°C

References

[1] golub ag,bdzhola vg,briukhovetska nv,balanda ao,kukharenko op,kotey im,ostrynska ov,yarmoluk sm. synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase ck2. eur j med chem.2011 mar;46(3):870-6.

Properties of TTP 22

storage temp.  Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility  insoluble in H2O; ≥16.5 mg/mL in DMSO; ≥7.85 mg/mL in EtOH with gentle warming and ultrasonic
form  solid
color  White to gray

Safety information for TTP 22

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for TTP 22

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