1,4-Dimethoxybenzene

Synonym(s):p-Methoxyanisole;Dimethylhydroquinone;Hydroquinone dimethyl ether;NSC 7483

CAS NO.：150-78-7
Empirical Formula: C8H10O2
Molecular Weight: 138.16
MDL number: MFCD00008401
EINECS: 205-771-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is 1,4-Dimethoxybenzene?

Chemical properties

white crystals or powder

Chemical properties

Hydroquinone Dimethyl Ether occurs in hyacinth oil and has also been identified in tea. It is a white, crystalline solid (mp 57–58°C) with an intensely sweet, somewhat herbal, nut-like odor.
Hydroquinone dimethyl ether is prepared by etherification of hydroquinone and is used in soap perfumes.

Chemical properties

p-Dimethoxybenzene has a bitter taste.

Occurrence

Reported found in hyacinth (Hyacinthus orientalis L.) essential oil, Rhodophyllus icterius, papaya, peppermint oil, green tea, cherimoya and cooked shrimp

The Uses of 1,4-Dimethoxybenzene

1,4-Dimethoxybenzene is used as Pharmaceutical Intermediate. It is used in some paints and as a diazo dye. It is also used in perfumes and flavors in order to its floral odor. In addition, it is used on greasy skin, and with sulfur to treat acne, or as a dandruff treatment.

The Uses of 1,4-Dimethoxybenzene

Weathering agent in paints and plastics, fixative in perfumes, dyes, resin intermediate, cosmetics, especially suntan preparations, flavoring.

Preparation

By methylation of hydroquinone using dimethyl sulfate and alkali.

Definition

ChEBI: 1,4-Dimethoxybenzene is a dimethoxybenzene.

Synthesis Reference(s)

Journal of the American Chemical Society, 83, p. 1251, 1961 DOI: 10.1021/ja01466a056

General Description

Colorless crystals.

Air & Water Reactions

Slightly water soluble .

Reactivity Profile

1,4-Dimethoxybenzene is an ether. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Flammability and Explosibility

Not classified

Purification Methods

Steam distil 1,4-dimethoxybenzene, then crystallise it from hexane or *benzene, and from MeOH or EtOH, but these are wasteful due to high solubilities. Dry it under vacuum. It also sublimes under vacuum. [Beilstein 6 IV 5718.]

Properties of 1,4-Dimethoxybenzene

Melting point:	54-56 °C(lit.)
Boiling point:	213 °C(lit.)
Density	1.053 g/mL at 25 °C(lit.)
vapor density	4.8 (vs air)
vapor pressure	<1 mm Hg ( 20 °C)
refractive index	1.5231 (estimate)
FEMA	2386 \| P-DIMETHOXYBENZENE
Flash point:	98 °C
storage temp.	Sealed in dry,Room Temperature
solubility	dioxane: 0.1 g/mL, clear
form	Crystalline Powder, Crystals, or Flakes
color	White
Specific Gravity	1.053
Odor	at 1.00 % in dipropylene glycol. sweet green new mown hay fennel
PH	7 (H2O, 20℃)(saturated solution)
explosive limit	1.2-5.6%(V)
Water Solubility	0.8 g/l (20 ºC)
Sensitive	Light Sensitive
JECFA Number	1250
BRN	774605
Dielectric constant	4.5（23℃）
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	150-78-7(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,4-dimethoxy-(150-78-7)
EPA Substance Registry System	p-Dimethoxybenzene (150-78-7)

Safety information for 1,4-Dimethoxybenzene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.