Trimethyl orthobutyrate

Synonym(s):1,1,1-Trimethoxybutane

CAS NO.：43083-12-1
Empirical Formula: C7H16O3
Molecular Weight: 148.2
MDL number: MFCD00008480
EINECS: 256-079-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-20 11:34:09

What is Trimethyl orthobutyrate?

Chemical properties

Clear colorless to slightly yellow liquid

The Uses of Trimethyl orthobutyrate

Trimethyl orthobutyrate has been used in the preparation of:

5-acetamido-9-O-butyroyl-3,5-dideoxy-D-glycero-2-nonulo pyranosonic acid
9-O-butyroyl-3,5-dideoxy-5-glycoloylamido-D-glycero-2-nonulo pyranosonic acid

The Uses of Trimethyl orthobutyrate

Trimethyl orthobutyrate can be used for:

Acylation at OH-9 of N-acetylneuraminic acid and N-glycoloylneuraminic acid to give the corresponding 9-O-acylated derivatives.
Conversion of 2-amino-N-(1-H-benzimidazol-2-yl)benzamide to 2-propyl-3-benzimidazolyl-4(3H)-quinazolinone.
Preparation of 2-propyl substituted benzimidazoles from 1,2-benzenediamines.

It can also be used in the total synthesis of dl-camptothecin, Olmesartan Medoxomil, DE and CDE ring analogs of camptothecin, and homologs of 1,25-dihydroxyvitamin D₃.

General Description

Kinetics and mechanism of gas-phase elimination of trimethyl orthobutyrate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr.

Properties of Trimethyl orthobutyrate

Boiling point:	145-147 °C (lit.)
Density	0.926 g/mL at 25 °C (lit.)
refractive index	1.402-1.404
Flash point:	50 °C
storage temp.	Flammables area
solubility	Chloroform, Ethyl Acetate
form	Liquid
color	Clear colorless to slightly yellow
Specific Gravity	0.926
BRN	1737319
CAS DataBase Reference	43083-12-1(CAS DataBase Reference)
NIST Chemistry Reference	Trimethyl orthobutyrate(43083-12-1)

Safety information for Trimethyl orthobutyrate

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.