TRIETHYL 2-PHOSPHONOBUTYRATE
Synonym(s):α-Diethylphosphonobutanoic acid ethyl ester;Ethyl 2-(diethoxyphosphoryl)butanoate;NSC 22423
- CAS NO.：17145-91-4
- Empirical Formula: C10H21O5P
- Molecular Weight: 252.24
- MDL number: MFCD00041347
- EINECS: 627-866-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-23 14:28:52
What is TRIETHYL 2-PHOSPHONOBUTYRATE?
Chemical properties
clear colorless liquid
The Uses of TRIETHYL 2-PHOSPHONOBUTYRATE
Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.
The Uses of TRIETHYL 2-PHOSPHONOBUTYRATE
Reactant for preparation of:
- Furospinosulin-1 and analogs as hypoxia-selective antitumor agents
- Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs
- Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents
- PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists
- Notch-sparing γ-secretase inhibitors derived from PPAR agonist library
- Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis
- Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)
- α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates
- Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)
- Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis
Properties of TRIETHYL 2-PHOSPHONOBUTYRATE
| Boiling point: | 152-154 °C14 mm Hg(lit.) |
| Density | 1.064 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| color | Clear colorless |
| Specific Gravity | 1.064 |
| Water Solubility | Not miscible or difficult to mix with water. |
| BRN | 1789280 |
Safety information for TRIETHYL 2-PHOSPHONOBUTYRATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TRIETHYL 2-PHOSPHONOBUTYRATE
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