Tributyltin chloride

Synonym(s):TBTC;Tributylchlorotin;Tributyltin chloride

CAS NO.：1461-22-9
Empirical Formula: C12H27ClSn
Molecular Weight: 325.51
MDL number: MFCD00000521
EINECS: 215-958-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-24 21:11:45

What is Tributyltin chloride?

Chemical properties

Colorless or light yellow clear liquid. Soluble in the common organic solvents; including alcohol, heptane, benzene, and toluene; insoluble in cold water, but hydrolyzes in hot water.

The Uses of Tributyltin chloride

Tributyltin Chloride is a triorganotin compound with insecticidal acitivity. It is an endocrine disruptor as well as an inhibitor for the V-ATPases (potential targets in the treatmen t of diseases such as osteoporosis and cancer). Tributyltin Chloride has the functions of antiseptic, sterilization and mildew proof and widely used in wood preservation, ship paint, etc. Further, it is used in hot end glass coating and rodent-repellent for cable coatings.

What are the applications of Application

TBTC is a useful organometallic for proteomics research

Preparation

Tributyltin chloride is prepared by a redistribution reaction by combining stannic chloride and tetrabutyltin:
3 (C4H9)4Sn + SnCl4 → 4 (C4H9)3SnCl.

Definition

ChEBI: Tributyltin chloride is an inorganic molecular entity.

Hazard

A poison by ingestion and skin contact. A severe eye irritant. Tributyl tin compounds are extremely toxic to marine life.

Flammability and Explosibility

Not classified

Toxicology

Tributyltin chloride (TBTCL) is a widely used biocide and heat stabiliser for PVC compositions. TBTCL has been detected in humans and may cause harmful effects on the thyroid, cardiovascular and other organs in humans. It is also an endocrine disruptor with toxic effects on the male reproductive system.TBTCL causes apoptosis and cell cycle arrest. Activation of endoplasmic reticulum stress and inhibition of autophagy are responsible for TBTCL-induced apoptosis and cell cycle arrest.

Properties of Tributyltin chloride

Melting point:	-9 °C
Boiling point:	171-173 °C25 mm Hg(lit.)
Density	1.2 g/mL at 25 °C(lit.)
vapor pressure	<0.01 mm Hg ( 20 °C)
refractive index	n20/D 1.492(lit.)
Flash point:	>230 °F
storage temp.	2-8°C
solubility	0.017g/l
form	liquid
color	colorless
Specific Gravity	1.186
Water Solubility	PRACTICALLY INSOLUBLE
Sensitive	Moisture Sensitive
BRN	3535715
Exposure limits	ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin) NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3
Stability:	Hygroscopic
CAS DataBase Reference	1461-22-9(CAS DataBase Reference)
NIST Chemistry Reference	Tri-n-butyltin chloride(1461-22-9)
EPA Substance Registry System	Tributyltin chloride (1461-22-9)

Safety information for Tributyltin chloride

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H372:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.