trans-Styrylacetic acid

Synonym(s):4-Phenyl-3-butenoic acid

white to yellow-brown cryst. powder or needles

trans-Styrylacetic acid (4-Phenyl-3-butenoic acid) was used as mechanism-based inhibitor of Peptidylglycine α-hydroxylating monooxygenase.

Journal of the American Chemical Society, 102, p. 2473, 1980 DOI: 10.1021/ja00527a064
The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 26, p. 2633, 1985 DOI: 10.1016/S0040-4039(00)98122-X

The polarized IR spectra of the hydrogen bond system in trans-styrylacetic acid has been studied.

Melting point:	84-86 °C(lit.)
Boiling point:	228.88°C (rough estimate)
Density	1.0281 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Refrigerator (+4°C)
form	Crystalline Powder or Needles
pka	4.46±0.10(Predicted)
color	White to yellow-brown

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.