trans-Dichlorodiamineplatinum(II)

Synonym(s):trans-Diamminedichloroplatinum(II);trans-Dichlorodiammineplatinum(II);trans-Platinum(II)diammine dichloride

CAS NO.：14913-33-8
Empirical Formula: Cl2H4N2Pt
Molecular Weight: 298.03
MDL number: MFCD00011623
EINECS: 238-980-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:42:46

trans-Dichlorodiamineplatinum(II) Structural

What is trans-Dichlorodiamineplatinum(II)?

Chemical properties

Yellow Powder or Crystal

The Uses of trans-Dichlorodiamineplatinum(II)

Transplatin is the trans stereoisomer impurity of trans-Dichlorodiamineplatinum(II), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.

The Uses of trans-Dichlorodiamineplatinum(II)

Transplatin is the trans stereoisomer impurity of Cisplatin (C499500), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.

Definition

ChEBI: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a trans planar configuration around the central platinum ion. Unlike its cis-isomer, cisplatin, it does not exhibit any useful pharmacological effect and is toxic.

Safety Profile

Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. See also PLATINUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx and Cl-.

Properties of trans-Dichlorodiamineplatinum(II)

Melting point:	340 °C (dec.)(lit.)
storage temp.	2-8°C
solubility	DMSO (Sparingly)
form	crystalline
color	yellow
Water Solubility	Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.
Exposure limits	ACGIH: TWA 0.002 mg/m3 NIOSH: IDLH 4 mg/m3; TWA 0.002 mg/m3
EPA Substance Registry System	Platinum, diamminedichloro-, (SP-4-1)- (14913-33-8)

Safety information for trans-Dichlorodiamineplatinum(II)

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Health Hazard GHS08
GHS Hazard Statements	H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.