trans-Dichlorodiamineplatinum(II)
Synonym(s):trans-Diamminedichloroplatinum(II);trans-Dichlorodiammineplatinum(II);trans-Platinum(II)diammine dichloride
- CAS NO.：14913-33-8
- Empirical Formula: Cl2H4N2Pt
- Molecular Weight: 298.03
- MDL number: MFCD00011623
- EINECS: 238-980-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:57
What is trans-Dichlorodiamineplatinum(II)?
Chemical properties
Yellow Powder or Crystal
The Uses of trans-Dichlorodiamineplatinum(II)
Transplatin is the trans stereoisomer impurity of trans-Dichlorodiamineplatinum(II), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.
The Uses of trans-Dichlorodiamineplatinum(II)
Transplatin is the trans stereoisomer impurity of Cisplatin (C499500), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.
Definition
ChEBI: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a trans planar configuration around the central platinum ion. Unlike its cis-isomer, cisplatin, it does not exhibit any useful pharmacological effect and is toxic.
Safety Profile
Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. See also PLATINUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx and Cl-.
Properties of trans-Dichlorodiamineplatinum(II)
| Melting point: | 340 °C (dec.)(lit.) |
| storage temp. | 2-8°C |
| solubility | DMSO (Sparingly) |
| form | crystalline |
| color | yellow |
| Water Solubility | Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water. |
| Exposure limits | ACGIH: TWA 0.002 mg/m3 NIOSH: IDLH 4 mg/m3; TWA 0.002 mg/m3 |
| EPA Substance Registry System | Platinum, diamminedichloro-, (SP-4-1)- (14913-33-8) |
Safety information for trans-Dichlorodiamineplatinum(II)
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for trans-Dichlorodiamineplatinum(II)
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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