Tomatidine hydrochloride
Synonym(s):3β-Hydroxy-5α-tomatidane hydrochloride;5α-Tomatidan-3β-ol hydrochloride;Tomatidine, HCl - CAS 6192-62-7 - Calbiochem
- CAS NO.:6192-62-7
- Empirical Formula: C27H46ClNO2
- Molecular Weight: 452.11
- MDL number: MFCD11521518
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 16:43:00
What is Tomatidine hydrochloride?
Chemical properties
Off-White Solid
The Uses of Tomatidine hydrochloride
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).
What are the applications of Application
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine
Biological Activity
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.
Mode of action
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
Properties of Tomatidine hydrochloride
Melting point: | 281-284°C (dec.) |
storage temp. | 2-8°C |
solubility | Methanol (Slightly) |
form | Off-white solid |
color | White to Off-White |
BRN | 3920740 |
Safety information for Tomatidine hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Tomatidine hydrochloride
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