TILIDINE HYDROCHLORIDE HEMIHYDRATE
- CAS NO.:27107-79-5
- Empirical Formula: C17H26ClNO3
- Molecular Weight: 327.85
- MDL number: MFCD02684014
- EINECS: 248-226-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:58
What is TILIDINE HYDROCHLORIDE HEMIHYDRATE?
Chemical properties
TILIDINE HYDROCHLORIDE HEMIHYDRATE is White Solid
Originator
Valoron,Goedecke,W. Germany,1970
The Uses of TILIDINE HYDROCHLORIDE HEMIHYDRATE
TILIDINE HYDROCHLORIDE HEMIHYDRATE is a controlled substance (opiate). Analgesic. It is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.
Manufacturing Process
In a first step, dimethylamine is reacted with crotonaldehyde to give 1-
(dimethylamino)-1,3-butadiene.
A solution of 194 grams (2 mols) of fresh-distilled 1-(dimethylamino)-1,3-
butadiene is combined at room temperature in a 1 liter round-bottom flask
with 352 grams (2 mols) atropic acid ethyl ester. After being stirred for about
10 minutes, the reaction mixture gradually becomes exothermic. By cooling
with ice water, the contents of the flask are kept at a temperature of 40° to
60°C. After the reaction has ceased, the mixture is kept overnight (about 8 to 24 hours) at room temperature. The next day the viscous product is dissolved
in 10 liters of ether and precipitated with ethereal hydrogen chloride forming
the corresponding hydrochloride. By fractional crystallization from ethyl
acetate/methyl ethyl ketone (10:1), an almost complete separation of the
isomeric cis/trans isomers (I) and (II) is achieved. The separation can be
carried out very easily due to the low solubility of the 1 1/2-hydrate of (I).
Therefore, during the crystallization a sufficient quantity of water for the
formation of the 1 1/2-hydrate of (I) is added to the mixture of solvents,
whereby (I) readily precipitates.
Isomer (I): 4-phenyl-3-cis-dimethylamino-4-cis-carbethoxy-?1-
cyclohexenehydrochloride, [ethyl-cis-3-(dimethylamino)-4-phenyl-1-
cyclohexene-4-carboxylate hydrochloride] , MP 84°C (the free base boils at
97.5° to 98°C at 0.01 mm pressure), 64.4% yield.
Isomer (II): 4-phenyl-3-trans-dimethylamino-4-trans-carbethoxy-?1-
cyclohexenehydrochloride, [ethyl-trans-3-(dimethylamino)-4-phenyl-1-
cyclohexene-4-carboxylate hydrochloride], MP 159°C (the free base boils at
95.5° to 96°C at 0.01 mm pressure), 22.2% yield.
Therapeutic Function
Analgesic
Properties of TILIDINE HYDROCHLORIDE HEMIHYDRATE
Melting point: | 149-152?C |
Flash point: | 9℃ |
storage temp. | -20°C Freezer |
solubility | Freely soluble in water, very soluble in methylene chloride, freely soluble in ethanol (96 per cent). |
form | Solid |
color | White to Off-White |
Stability: | Hygroscopic |
Safety information for TILIDINE HYDROCHLORIDE HEMIHYDRATE
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for TILIDINE HYDROCHLORIDE HEMIHYDRATE
New Products
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