Tigogenin
Synonym(s):(25R)-5α-Spirostan-3β-ol
- CAS NO.:77-60-1
- Empirical Formula: C27H44O3
- Molecular Weight: 416.64
- MDL number: MFCD00067287
- EINECS: 201-041-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-11 14:08:43
What is Tigogenin?
Description
Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.
Chemical properties
mp 196-208C° LOD ≤0.5%
The Uses of Tigogenin
Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.
Definition
ChEBI: Tigogenin is a widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. It has a role as a gout suppressant and a plant metabolite.
Properties of Tigogenin
Melting point: | 202-204°C |
Boiling point: | 474.91°C (rough estimate) |
alpha | -68 º (c=0.8g/100ml, CHCl3) |
Density | 1.0362 (rough estimate) |
refractive index | 1.4700 (estimate) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | Chloroform (Slightly) |
pka | 15.14±0.70(Predicted) |
form | Solid |
color | Off-White |
CAS DataBase Reference | 77-60-1(CAS DataBase Reference) |
NIST Chemistry Reference | Tigogenin(77-60-1) |
Safety information for Tigogenin
Computed Descriptors for Tigogenin
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION XANTHAN GUM Racecadotril SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Folic Acid Impurity G Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
You may like
-
Tigogenin CAS 77-60-1View Details
77-60-1 -
88150-47-4 99%View Details
88150-47-4 -
177-11-7 1,4-Dioxa-8-azaspiro[4.5]decane 98+View Details
177-11-7 -
217299-03-1 98+View Details
217299-03-1 -
(R)-3-Aminobutanenitrile Hydrochloride 98+View Details
1073666-55-3 -
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 39124-20-4 98+View Details
39124-20-4 -
2006278-26-6 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 98+View Details
2006278-26-6 -
39856-50-3 98+View Details
39856-50-3