Tigogenin
Synonym(s):(25R)-5α-Spirostan-3β-ol
- CAS NO.:77-60-1
- Empirical Formula: C27H44O3
- Molecular Weight: 416.64
- MDL number: MFCD00067287
- EINECS: 201-041-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Tigogenin?
Description
Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.
Chemical properties
mp 196-208C° LOD ≤0.5%
The Uses of Tigogenin
Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.
Definition
ChEBI: Tigogenin is a widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. It has a role as a gout suppressant and a plant metabolite.
Properties of Tigogenin
Melting point: | 202-204°C |
Boiling point: | 474.91°C (rough estimate) |
alpha | -68 º (c=0.8g/100ml, CHCl3) |
Density | 1.0362 (rough estimate) |
refractive index | 1.4700 (estimate) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | Chloroform (Slightly) |
pka | 15.14±0.70(Predicted) |
form | Solid |
color | Off-White |
CAS DataBase Reference | 77-60-1(CAS DataBase Reference) |
NIST Chemistry Reference | Tigogenin(77-60-1) |
Safety information for Tigogenin
Computed Descriptors for Tigogenin
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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