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HomeProduct name listTigogenin

Tigogenin

Synonym(s):(25R)-5α-Spirostan-3β-ol

  • CAS NO.:77-60-1
  • Empirical Formula: C27H44O3
  • Molecular Weight: 416.64
  • MDL number: MFCD00067287
  • EINECS: 201-041-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-11 14:08:43
Tigogenin Structural

What is Tigogenin?

Description

Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.

Chemical properties

mp 196-208C° LOD ≤0.5%

The Uses of Tigogenin

Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.

Definition

ChEBI: Tigogenin is a widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. It has a role as a gout suppressant and a plant metabolite.

Properties of Tigogenin

Melting point: 202-204°C
Boiling point: 474.91°C (rough estimate)
alpha  -68 º (c=0.8g/100ml, CHCl3)
Density  1.0362 (rough estimate)
refractive index  1.4700 (estimate)
storage temp.  -20°C Freezer, Under inert atmosphere
solubility  Chloroform (Slightly)
pka 15.14±0.70(Predicted)
form  Solid
color  Off-White
CAS DataBase Reference 77-60-1(CAS DataBase Reference)
NIST Chemistry Reference Tigogenin(77-60-1)

Safety information for Tigogenin

Computed Descriptors for Tigogenin

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