DIGITONIN
Synonym(s):Digitin
- CAS NO.:11024-24-1
- Empirical Formula: C56H92O29
- Molecular Weight: 1229.31
- MDL number: MFCD00077729
- EINECS: 234-255-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is DIGITONIN?
Chemical properties
white crystalline powder
The Uses of DIGITONIN
Digitonin has been used in a study to assess a procedure for isolating mitochondria from ascites tumor cells. It has also been used in a study to investigate its effect on the cytotoxicity of plant secondary metabolites in cancer cells. This mild nonionic detergent can be used to solubilize receptors and permeabilize cellular and nuclear membranes.
The Uses of DIGITONIN
enhances membrane permeability
The Uses of DIGITONIN
Natural surfactant useful for receptor solubilization and cell permeabilization, e.g., blood platelets, hepatocytes, yeast or tumor cells
The Uses of DIGITONIN
Clinical reagent (cholesterol determination).
What are the applications of Application
Digitonin is a steroidal saponin and non-ionic biodetergent used to solubilize membrane-bound proteins.
General Description
Crystals or white powder.
Air & Water Reactions
Forms soapy aqueous suspension .
Reactivity Profile
DIGITONIN is incompatible with strong oxidizing agents and strong acids. (NTP, 1992
Fire Hazard
Flash point data for DIGITONIN are not available; however, DIGITONIN is probably combustible.
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Mutation data reported. See also DIGITALIS. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
This digitoxin hexa-glycoside can be recrystallised from aqueous 85% EtOH or MeOH/diethyl ether. It is purified by preparative paper chromatography and developed with the upper phase of a mixture of nBuOH/H2O/AcOH (4:5:1), and the spot (RF 0.36) is eluted with 25% CCl3CO2H in CHCl3. It has also been purified by countercurrent distribution. It forms an ethanolate, and complexes with cholesterol and other sterols. [Ruhenstroth-Bauer & Breitenfeld Hoppe Seyler's Z Physiol Chem 302 111 1955, Grisvold J Am Pharm Assoc 23 664 1934, Beilstein 19 IV 1243.]
Properties of DIGITONIN
Melting point: | 230-240 °C (dec.)(lit.) |
Boiling point: | 788.4°C (rough estimate) |
alpha | D20 -54° (0.45 g in 15.8 ml methanol) |
Density | 1.1421 (rough estimate) |
refractive index | -52 ° (C=1, EtOH) |
storage temp. | Sealed in dry,Room Temperature |
solubility | H2O: 10 mg/mL at 95 °C hot, clear, colorless |
form | White powder |
pka | 12.68±0.70(Predicted) |
color | white |
optical activity | [α]20/D 54°, c = 2.8 in methanol(lit.) |
Merck | 14,3161 |
BRN | 78654 |
Stability: | Hygroscopic |
EPA Substance Registry System | Digitonin (11024-24-1) |
Safety information for DIGITONIN
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P314:Get medical advice/attention if you feel unwell. |
Computed Descriptors for DIGITONIN
InChIKey | FAAZZWIYYDUONB-JYIJKGCVSA-N |
DIGITONIN manufacturer
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