Ginsenoside Rh2

Synonym(s):(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl-β-D-glucopyranoside;20(S)-Ginsenoside-Rh2

CAS NO.：78214-33-2
Empirical Formula: C36H62O8
Molecular Weight: 622.88
MDL number: MFCD00800712
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Ginsenoside Rh2?

Description

Ginsenoside Rh₂ is a steroid glycoside found in plants of the genus Panax that has diverse biological activities. It inhibits release of β-hexosaminidase from RBL-2H3 cells (IC₅₀ = 100 μM) and inhibits the IgE-dependent passive cutaneous anaphylaxis reaction in mice at a dose of 25 mg/kg. It inhibits growth of HRA ovarian and BxPC-3 pancreatic cancer cells in a dose-dependent manner. In vivo, ginsenoside Rh₂ decreases immobility time in the forced swim test in a mouse model of colorectal carcinoma. Ginsenoside Rh₂ also reduces infarct volume in a rat model of ischemia-reperfusion-induced brain injury.

Chemical properties

White solid

The Uses of Ginsenoside Rh2

20(S)-Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng that has been shown to exhibit antibacterial effects in vitro.

What are the applications of Application

20(S)- Ginsenoside Rh2 is a plant glycoside with anti-cancer proliferation and chemopreventive effects

Definition

ChEBI: A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.

Properties of Ginsenoside Rh2

Melting point:	139-144 °C
Boiling point:	726.4±60.0 °C(Predicted)
Density	1.19±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form	neat
pka	12.91±0.70(Predicted)
form	Solid
color	White
CAS DataBase Reference	78214-33-2(CAS DataBase Reference)

Safety information for Ginsenoside Rh2

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.