Tiamulin fumarate
Synonym(s):Thiamutilin fumarate
- CAS NO.:55297-96-6
- Empirical Formula: C32H51NO8S
- Molecular Weight: 609.82
- MDL number: MFCD27966802
- EINECS: 259-581-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-04 20:40:58
What is Tiamulin fumarate?
Chemical properties
White Solid. soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide.
The Uses of Tiamulin fumarate
Tiamulin fumarate is a semisynthetic pleuromutilin antibiotic that binds to the ribosomal peptidyl transferase centre and inhibits protein synthesis. It is a derivative of Pleuromutilin with Antibacterial that targets Gram-positive bacteria as well as a few mycoplasma species.
What are the applications of Application
Tiamulin fumarate is an antibacterial and a derivative of Pleuromutilin
What are the applications of Application
Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity. The hemi-fumarate provides a stable salt with improved water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action of inhibiting protein synthesis by binding to domain V of 23S rRNA.
Indications
Tiamulin fumarate is mainly used for Mycoplasma suis pneumonia, Haemophilus parasuis, infectious pleuropneumonia and dysentery caused by Treponema swine, and also for chronic respiratory tract of poultry, Mycoplasma pneumonia, infectious rhinitis, Escherichia coli, duck Infectious serositis.
Health Hazard
Inhalation may irritate (cough, short breathing, difficulty in breathing). Headache.
It may cause moderate irritation, including a burning sensation, tearing, redness, or swelling. Itching.
Causes serious eye irritation. Redness, itching, tears. Stinging.
It may cause irritation to the digestive tract. Abdominal pain, nausea.
Mode of action
Tiamulin fumarate is a bacteriostatic antibiotic belonging to the pleuromutilin class, which inhibit protein synthesis by targeting the 50S bacterial ribosomal subunit and binding to peptidyl transferase, the enzyme responsible for forming peptide bonds between amino acids.
Properties of Tiamulin fumarate
Melting point: | 147-148°C |
Boiling point: | 563℃ |
Flash point: | >110°(230°F) |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
form | neat |
form | Solid |
color | White |
Water Solubility | Soluble in water |
Merck | 13,9495 |
CAS DataBase Reference | 55297-96-6(CAS DataBase Reference) |
Safety information for Tiamulin fumarate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Tiamulin fumarate
InChIKey | YXQXDXAHCSEVSD-IHAONTCTSA-N |
SMILES | C(/C(=O)O)=C\C(=O)O.C[C@H]1[C@@H]([C@](C[C@@H](OC(=O)CSCCN(CC)CC)C2([C@H](C)CCC31CCC(=O)[C@]32[H])C)(C)C=C)O |&1:9,10,11,13,27,36,r| |
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