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HomeProduct name listThymopentin

Thymopentin

Synonym(s):Arg-Lys-Asp-Val-Tyr;TP5

  • CAS NO.:69558-55-0
  • Empirical Formula: C30H49N9O9
  • Molecular Weight: 679.77
  • MDL number: MFCD00214200
  • EINECS: 811-641-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 11:59:05
Thymopentin Structural

What is Thymopentin?

Description

Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.

Originator

Janssen (Belgium)

The Uses of Thymopentin

Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.

The Uses of Thymopentin

immunoregulator

Definition

ChEBI: Thymopentin is an oligopeptide.

brand name

SINTOMODULINA; TIMUNOX

Clinical Use

Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.

References

Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.

Properties of Thymopentin

Density  1.44±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form  Powder
pka 3.07±0.10(Predicted)
color  White
CAS DataBase Reference 69558-55-0(CAS DataBase Reference)

Safety information for Thymopentin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P330:Rinse mouth.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for Thymopentin

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