THIP HYDROCHLORIDE
- CAS NO.：64603-91-4
- Empirical Formula: C6H8N2O2
- Molecular Weight: 140.14
- MDL number: MFCD00242754
- EINECS: 264-963-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-26 17:16:27
What is THIP HYDROCHLORIDE?
Description
Gaboxadol HCl (64603-91-4) is a GABA-A receptor agonist. Hypnotic agent.
The Uses of THIP HYDROCHLORIDE
GABAa agonist, GABAc antagonist
What are the applications of Application
THIP hydrochloride is a GABAA receptor agonist and GABAC receptor antagonist
Definition
ChEBI: 4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol is an oxazole.
Biological Activity
Systemically active GABA A receptor agonist and GABA C receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
References
1) Meera et al. (2011), Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors; J. Neurophysiol., 106 2057
Properties of THIP HYDROCHLORIDE
| Melting point: | 242-244° (dec) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | ethanol: 0.91 mg/mL |
| form | solid |
| pka | pKa (water, 25°): 4.44 ±0.03; 8.48 ±0.04 |
| color | white |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
Safety information for THIP HYDROCHLORIDE
Computed Descriptors for THIP HYDROCHLORIDE
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