1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
Synonym(s):1-( iso-Propyl)-1H-benzotriazole-5-carboxylic acid;1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid;GPR109b Agonist - CAS 306935-41-1 - Calbiochem
- CAS NO.：306935-41-1
- Empirical Formula: C10H11N3O2
- Molecular Weight: 205.21
- MDL number: MFCD01570664
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID?
Description
IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a.
What are the applications of Application
IBC 293 is a selective HM74/GPR109b receptor agonist
Definition
ChEBI: 1-propan-2-yl-5-benzotriazolecarboxylic acid is a member of benzotriazoles.
Biological Activity
Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes.
References
1) Semple et al. (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b; J. Med. Chem., 49 1227
Properties of 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
| Melting point: | 229-230°C |
| Boiling point: | 413.9±18.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Light brown solid |
| pka | 3.50±0.30(Predicted) |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 306935-41-1(CAS DataBase Reference) |
Safety information for 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
Computed Descriptors for 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
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