1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID

Synonym(s):1-( iso-Propyl)-1H-benzotriazole-5-carboxylic acid;1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid;GPR109b Agonist - CAS 306935-41-1 - Calbiochem

CAS NO.：306935-41-1
Empirical Formula: C10H11N3O2
Molecular Weight: 205.21
MDL number: MFCD01570664
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Structural

What is 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID?

Description

IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a.

What are the applications of Application

IBC 293 is a selective HM74/GPR109b receptor agonist

Definition

ChEBI: 1-propan-2-yl-5-benzotriazolecarboxylic acid is a member of benzotriazoles.

Biological Activity

Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes.

References

1) Semple et al. (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b; J. Med. Chem., 49 1227

Properties of 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID

Melting point:	229-230°C
Boiling point:	413.9±18.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	Soluble in DMSO (up to 25 mg/ml).
form	Light brown solid
pka	3.50±0.30(Predicted)
color	Off-white
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference	306935-41-1(CAS DataBase Reference)