Thiazovivin

Synonym(s):N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide

CAS NO.：1226056-71-8
Empirical Formula: C15H13N5OS
Molecular Weight: 311.36
MDL number: MFCD16495823
EINECS: 808-340-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-07-12 16:54:15

What is Thiazovivin?

Description

Thiazovivin (1226056-71-8) dramatically improves (200-fold) the efficiency of induced pluripotent stem cell generation from human fibroblasts.1 Induces direct conversion of porcine embryonic fibroblasts into adipocytes.2?Cell permeable.

The Uses of Thiazovivin

A compound that improves the survival of human embryonic stem cells (hESCs) upon trypsinization. In combination with ALK5 (TGFβ receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901 (P217450), Thiazovivin promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method

The Uses of Thiazovivin

Thiazovivin has been used in the generation of induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) from human urine cells. It has also been used to study the the effect of pro-fibrotic inhibition on cardiac reprogramming.

What are the applications of Application

Thiazovivin is a ROCK inhibitor that is also known to enhance the efficiency of fibroblast reprogramming

Biochem/physiol Actions

Thiazovivin is an inhibitor of Rho associated coiled-coil containing protein kinase (ROCK). In vitro studies prove that thiazovivin is efficient in stimulating better morphology, expression of ionic transporter and protein involved in cell adhesion.

storage

-20°C

References

1) Lin et al. (2009), A chemical platform for improved induction of iPSC; Nature Methods, 6 805 2) Zhu et al. (2012), Direct conversion of porcine embryonic fibroblasts into adipocytes by chemical molecules; Cell Reprogram., 14 99

Properties of Thiazovivin

Density	1.379
storage temp.	-20°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
pka	13.87±0.46(Predicted)
color	, white to beige to brown
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety information for Thiazovivin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.