Thiazole-5-carboxaldehyde

CAS NO.：1003-32-3
Empirical Formula: C4H3NOS
Molecular Weight: 113.14
MDL number: MFCD02179516
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:38

What is Thiazole-5-carboxaldehyde?

Chemical properties

White to brown liquid or solid

The Uses of Thiazole-5-carboxaldehyde

Thiazole-5-carboxaldehyde is used in the synthesis of imidazoles with cardiomyocyte proliferation activity for heart disease treatments.

Synthesis Reference(s)

Synthetic Communications, 25, p. 4081, 1995 DOI: 10.1080/00397919508011485
Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146

Purification Methods

Dry the aldehyde over Na2SO4 and fractionate it in a vacuum. The 2,4-dinitrophenylhydrazone forms red crystals from MeOH with m 238-240o, and the semicarbazone has m 210-212o (from MeOH). [Erne et al. Helv Chim Acta 34 148 1951, Beilstein 27 III/IV 2615.]

Properties of Thiazole-5-carboxaldehyde

Melting point:	229 °C (decomp)
Boiling point:	92-94 °C/16 mmHg
Density	1.304 g/mL at 25 °C
refractive index	1.5874
Flash point:	98 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to lump to clear liquid
pka	0.94±0.10(Predicted)
color	White or Colorless to Yellow
CAS DataBase Reference	1003-32-3(CAS DataBase Reference)

Safety information for Thiazole-5-carboxaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.