1,3-Thiazole-2-carbaldehyde

CAS NO.：10200-59-6
Empirical Formula: C4H3NOS
Molecular Weight: 113.14
MDL number: MFCD00142924
EINECS: 688-154-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-19 17:35:41

What is 1,3-Thiazole-2-carbaldehyde?

Chemical properties

Colorless to light yellow liqui

The Uses of 1,3-Thiazole-2-carbaldehyde

2-Thiazolecarboxaldehyde is a useful building block for taxane analogs.

Synthesis Reference(s)

Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146

General Description

2-Thiazolecarboxaldehyde is a thiazole aldehyde derivative. It undergoes Baylis–Hillman reaction with methyl acrylate catalyzed by DABCO (1,4-diazabicyclo[2.2.2]octane). The reaction mechanism has been studied by electrospray ionization mass spectrometry (ESI-MS).

Properties of 1,3-Thiazole-2-carbaldehyde

Boiling point:	61-63 °C/15 mmHg (lit.)
Density	1.288 g/mL at 25 °C (lit.)
refractive index	n20/D 1.574(lit.)
Flash point:	154 °F
storage temp.	2-8°C
form	Liquid
pka	0.44±0.10(Predicted)
color	Colorless to pale yellow
Water Solubility	soluble
CAS DataBase Reference	10200-59-6(CAS DataBase Reference)

Safety information for 1,3-Thiazole-2-carbaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…