Tetrakis(hydroxymethyl)phosphonium chloride

Synonym(s):THPC solution

CAS NO.：124-64-1
Empirical Formula: C4H12ClO4P
Molecular Weight: 190.56
MDL number: MFCD00031687
EINECS: 204-707-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

Tetrakis(hydroxymethyl)phosphonium chloride Structural

What is Tetrakis(hydroxymethyl)phosphonium chloride ?

Chemical properties

Clear light pink or yellow-green solution

The Uses of Tetrakis(hydroxymethyl)phosphonium chloride

Tetrakis(hydroxymethyl)phosphonium chloride solution (80% in H₂O) has been used as a reducing agent and stabilizing ligand for the synthesis of gold nanoparticles (AuNPs) from gold(III) chloride trihydrate (HAuCl₄.3H₂O). It is a tetra-functional, amine-reactive, aqueous crosslinker that can be used for tuning the properties of protein-based hydrogels for 3D cell encapsulation applications.

The Uses of Tetrakis(hydroxymethyl)phosphonium chloride

Flame-retarding agent for cotton fabrics. May be used in combination with triethylolamine and urea (Roxel process) or with triethanolamine and tris(1-aziridinyl) phosphine oxide.

Definition

A crystalline compound made by the reaction of phosphine, formaldehyde, and hydrochloric acid.

General Description

Clear slightly viscous,colorless to yellow liquid (20% H2O solution).

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Tetrakis(hydroxymethyl)phosphonium chloride reacts vigorously with oxidizers and alkalis. Reacts with cellulose.

Health Hazard

ACUTE/CHRONIC HAZARDS: Tetrakis(hydroxymethyl)phosphonium chloride may be corrosive. When heated to decomposition, it may emit very toxic fumes of POx, hydrogen chloride and bis(chloromethyl)ether. Decomposition of Tetrakis(hydroxymethyl)phosphonium chloride in an aqueous environment may produce phosphine, formaldehyde and hydrogen chloride.

Fire Hazard

Tetrakis(hydroxymethyl)phosphonium chloride is probably combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from AcOH and dry it at 100o in a vacuum. An 80% w/v aqueous solution has d4 1.33 [Reeves J Am Chem Soc 77 3923 1955]. [Beilstein 1 IV 3062.]

Properties of Tetrakis(hydroxymethyl)phosphonium chloride

Melting point:	154°C
Boiling point:	115°C/760mmHg
Density	1.341 g/mL at 25 °C
vapor pressure	0Pa at 25℃
refractive index	n20/D 1.512
form	Solution
pka	6.05[at 20 ℃]
color	Clear light pink or yellow-green
Water Solubility	>=10 g/100 mL at 20 ºC
BRN	3631669
InChI	InChI=1S/C4H12O4P.ClH/c5-1-9(2-6,3-7)4-8;/h5-8H,1-4H2;1H/q+1;/p-1
CAS DataBase Reference	124-64-1(CAS DataBase Reference)
EPA Substance Registry System	Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1)

Safety information for Tetrakis(hydroxymethyl)phosphonium chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H290:Corrosive to Metals H314:Skin corrosion/irritation H317:Sensitisation, Skin H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.