TETRAETHYL METHYLENEDIPHOSPHONATE
Synonym(s):Bis(diethoxyphosphinyl)methane;Methylenediphosphonic acid tetraethylester;NSC 133889
- CAS NO.：1660-94-2
- Empirical Formula: C9H22O6P2
- Molecular Weight: 288.21
- MDL number: MFCD00039887
- EINECS: 216-764-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 16:58:51
What is TETRAETHYL METHYLENEDIPHOSPHONATE?
Chemical properties
clear yellow to yellow-brown liquid
The Uses of TETRAETHYL METHYLENEDIPHOSPHONATE
Tetraethyl methylidenebisphosphonate, can be used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters as potent anti-inflammatory agents. It is also an intermediate for the synthesis of new bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity.
The Uses of TETRAETHYL METHYLENEDIPHOSPHONATE
Reactant for synthesis of:
- Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
- Unnatural alpha-amino acid derivatives containing gem-biphosphonates
- Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
- Lycopene via Wittig-Horner reaction
- Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
- Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase
Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition
Synthesis Reference(s)
Synthetic Communications, 20, p. 1865, 1990 DOI: 10.1080/00397919008053112
Tetrahedron Letters, 34, p. 1515, 1993 DOI: 10.1016/S0040-4039(00)60333-7
Properties of TETRAETHYL METHYLENEDIPHOSPHONATE
| Boiling point: | 171-174 °C11 mm Hg(lit.) |
| Density | 1.16 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Liquid |
| color | Clear yellow to yellow-brown |
| Specific Gravity | 1.160 |
| Water Solubility | Slightly miscible with water. |
| BRN | 1813241 |
| CAS DataBase Reference | 1660-94-2(CAS DataBase Reference) |
| EPA Substance Registry System | Phosphonic acid, methylenebis-, tetraethyl ester (1660-94-2) |
Safety information for TETRAETHYL METHYLENEDIPHOSPHONATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TETRAETHYL METHYLENEDIPHOSPHONATE
| InChIKey | STJWVOQLJPNAQL-UHFFFAOYSA-N |
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product: 1660-94-2 Tetraethyl methylidenediphosphonate 99%
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