TETRAETHYL METHYLENEDIPHOSPHONATE

Synonym(s):Bis(diethoxyphosphinyl)methane;Methylenediphosphonic acid tetraethylester;NSC 133889

CAS NO.：1660-94-2
Empirical Formula: C9H22O6P2
Molecular Weight: 288.21
MDL number: MFCD00039887
EINECS: 216-764-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-20 16:58:51

TETRAETHYL METHYLENEDIPHOSPHONATE Structural

What is TETRAETHYL METHYLENEDIPHOSPHONATE?

Chemical properties

clear yellow to yellow-brown liquid

The Uses of TETRAETHYL METHYLENEDIPHOSPHONATE

Tetraethyl methylidenebisphosphonate, can be used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters as potent anti-inflammatory agents. It is also an intermediate for the synthesis of new bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity.

The Uses of TETRAETHYL METHYLENEDIPHOSPHONATE

Reactant for synthesis of:

Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Unnatural alpha-amino acid derivatives containing gem-biphosphonates
Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
Lycopene via Wittig-Horner reaction
Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase

Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition

Synthesis Reference(s)

Synthetic Communications, 20, p. 1865, 1990 DOI: 10.1080/00397919008053112
Tetrahedron Letters, 34, p. 1515, 1993 DOI: 10.1016/S0040-4039(00)60333-7

Properties of TETRAETHYL METHYLENEDIPHOSPHONATE

Boiling point:	171-174 °C11 mm Hg(lit.)
Density	1.16 g/mL at 25 °C(lit.)
refractive index	n20/D 1.442(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Liquid
color	Clear yellow to yellow-brown
Specific Gravity	1.160
Water Solubility	Slightly miscible with water.
BRN	1813241
CAS DataBase Reference	1660-94-2(CAS DataBase Reference)
EPA Substance Registry System	Phosphonic acid, methylenebis-, tetraethyl ester (1660-94-2)

Safety information for TETRAETHYL METHYLENEDIPHOSPHONATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.