Tetraethyl orthocarbonate
- CAS NO.:78-09-1
- Empirical Formula: C9H20O4
- Molecular Weight: 192.25
- MDL number: MFCD00009221
- EINECS: 201-082-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-15 16:24:08
What is Tetraethyl orthocarbonate?
Chemical properties
clear colorless liquid
The Uses of Tetraethyl orthocarbonate
Tetraethyl Orthocarbonate is used in the synthesis of chemokine receptor-5 inhibitors against HIV-1, benzobisoxazoles and in the preparation of organic semiconductors. It is also employed in the synthesis of 2,7-dimethylene-1,4,6,9-tetraoxaspiro[4,4]nonane and in the synthesis of cross linked poly(orthocarbonate)s used as organic solvent absorbent.
Purification Methods
Likely impurities are hydrolysis products. Shake the orthocarbonate with brine (saturated NaCl, dilute with a little Et2O if amount of material is small) and dry (MgSO4). The organic layer is filtered off and evaporated, and the residue is distilled through a helices packed fractionating column with a total reflux partial take-off head. All distillations can be done at atmospheric pressure in an inert atmosphere (e.g. N2). [Roberts & McMahon Org Synth Coll Vol IV 457 1963, Connolly & Dyson J Chem Soc 828 1937, Tieckelmann & Post J Org Chem 13 266 1948, for review see Kantlehner et al. Justus Liebigs Ann Chem 507 207 1982, Beilstein 3 IV 6.]
Properties of Tetraethyl orthocarbonate
Melting point: | 222 °C |
Boiling point: | 159 °C (lit.) |
Density | 0.919 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 127 °F |
storage temp. | Inert atmosphere,Room Temperature |
solubility | soluble in Chloroform, Methanol |
form | clear liquid |
Specific Gravity | 0.919 |
color | Colorless to Almost colorless |
Water Solubility | Insoluble |
Sensitive | Moisture Sensitive |
BRN | 1747401 |
CAS DataBase Reference | 78-09-1(CAS DataBase Reference) |
NIST Chemistry Reference | Ethane, 1,1',1'',1'''-[methanetetrayltetrakis(oxy)]tetrakis-(78-09-1) |
EPA Substance Registry System | Ethane, 1,1',1'',1'''-[methanetetrayltetrakis(oxy)]tetrakis- (78-09-1) |
Safety information for Tetraethyl orthocarbonate
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for Tetraethyl orthocarbonate
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