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HomeProduct name listTetraethyl orthocarbonate

Tetraethyl orthocarbonate

  • CAS NO.:78-09-1
  • Empirical Formula: C9H20O4
  • Molecular Weight: 192.25
  • MDL number: MFCD00009221
  • EINECS: 201-082-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-15 16:24:08
Tetraethyl orthocarbonate Structural

What is Tetraethyl orthocarbonate?

Chemical properties

clear colorless liquid

The Uses of Tetraethyl orthocarbonate

Tetraethyl Orthocarbonate is used in the synthesis of chemokine receptor-5 inhibitors against HIV-1, benzobisoxazoles and in the preparation of organic semiconductors. It is also employed in the synthesis of 2,7-dimethylene-1,4,6,9-tetraoxaspiro[4,4]nonane and in the synthesis of cross linked poly(orthocarbonate)s used as organic solvent absorbent.

Purification Methods

Likely impurities are hydrolysis products. Shake the orthocarbonate with brine (saturated NaCl, dilute with a little Et2O if amount of material is small) and dry (MgSO4). The organic layer is filtered off and evaporated, and the residue is distilled through a helices packed fractionating column with a total reflux partial take-off head. All distillations can be done at atmospheric pressure in an inert atmosphere (e.g. N2). [Roberts & McMahon Org Synth Coll Vol IV 457 1963, Connolly & Dyson J Chem Soc 828 1937, Tieckelmann & Post J Org Chem 13 266 1948, for review see Kantlehner et al. Justus Liebigs Ann Chem 507 207 1982, Beilstein 3 IV 6.]

Properties of Tetraethyl orthocarbonate

Melting point: 222 °C
Boiling point: 159 °C (lit.)
Density  0.919 g/mL at 25 °C (lit.)
refractive index  n20/D 1.392(lit.)
Flash point: 127 °F
storage temp.  Inert atmosphere,Room Temperature
solubility  soluble in Chloroform, Methanol
form  clear liquid
Specific Gravity 0.919
color  Colorless to Almost colorless
Water Solubility  Insoluble
Sensitive  Moisture Sensitive
BRN  1747401
CAS DataBase Reference 78-09-1(CAS DataBase Reference)
NIST Chemistry Reference Ethane, 1,1',1'',1'''-[methanetetrayltetrakis(oxy)]tetrakis-(78-09-1)
EPA Substance Registry System Ethane, 1,1',1'',1'''-[methanetetrayltetrakis(oxy)]tetrakis- (78-09-1)

Safety information for Tetraethyl orthocarbonate

Signal word Warning
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H226:Flammable liquids
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P240:Ground/bond container and receiving equipment.
P241:Use explosion-proof electrical/ventilating/lighting/…/equipment.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.
P501:Dispose of contents/container to..…

Computed Descriptors for Tetraethyl orthocarbonate

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