tert-Butyl 2-(dimethoxyphosphoryl)acetate

Synonym(s):tert-Butyl ((oxo)dimethoxyphosphino)acetate;tert-Butyl (dimethoxyphosphinyl)acetate;Dimethyl (tert-butoxycarbonyl)methylphosphonate

Reactant for:

Preparation of phosphonate terminated PPH dendrimers as anti-HIV-1 agents
Preparation of monodehydro diketopiperazines from ketoacyl amino acid amides via acid-catalyzed cyclization
Preparation of α,β-unsaturated esters for use in the guanidine-catalyzed oxa-Michael addition
Preparation of myxopyronin B and desmethyl myxopyronin B analogs, with antibacterial activity and inhibitory activity against bacterial RNA polymerase
Allylation and subsequent ring-closing metathesis in presence of Grubbs′ catalyst or intramolecular rhodium-catalyzed cyclopropanation reactions

tert-Butyl P,P-dimethylphosphonoacetate is a Horner-Wittig reagent giving preferentially (E)-α,β-unsat. esters which are mildly saponified with acid

Boiling point:	86-87 °C0.02 mm Hg(lit.)
Density	1.131 g/mL at 20 °C(lit.)
refractive index	n20/D 1.434
Flash point:	110 ºC
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	clear liquid
color	Colorless to Almost colorless
BRN	4861886
InChI	InChI=1S/C8H17O5P/c1-8(2,3)13-7(9)6-14(10,11-4)12-5/h6H2,1-5H3

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.