Tenofovir
Synonym(s):(R)-9-(2-Phosphonomethoxypropyl)adenine;(R)-PMPA;[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid monohydrate;1-(6-Aminopurin-9-yl) propan-2-yl-oxymethylphosphonic acid;TEN
- CAS NO.：147127-20-6
- Empirical Formula: C9H14N5O4P
- Molecular Weight: 287.21
- MDL number: MFCD07357269
- EINECS: 604-571-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-13 18:00:15
What is Tenofovir?
Description
Tenofovir is an analog of adenosine monophosphate that has antiviral activity. It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ. For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) , which increases the intracellular diphosphorylated compound >1,000-
The Uses of Tenofovir
Tenofovir is a drug used for the treatment of chronic heptatitis B as well as prevention and treatment of HIV/AIDS. It is a kind of nucleotide analog, acting as the reverse-transcriptase inhibitor (NtRTI). It inhibits the activity of HIV reverse transcriptase through competing with the natural substrate deoxyadenosine 5’-triphosphate, causing the termination of DNA chain.
What are the applications of Application
Tenofovir is a selective HIV reverse transcriptase (HIV-1 RT) inhibitor
Properties of Tenofovir
| Melting point: | 276-280°C |
| Boiling point: | 616.1±65.0 °C(Predicted) |
| Density | 1.79±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Aqueous Acid (Sparingly), DMSO (Slightly, Heated), Water (Slightly, Heated) |
| form | powder |
| color | white to beige |
| Water Solubility | 13.4 mg/mL (25 ºC) |
Safety information for Tenofovir
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tenofovir
Abamectin manufacturer
VGS SYNTHESIS PRIVATE LIMITED
SPC LIFESCIENCES PVT. LTD
BIOCHEMICAL & SYNTHETIC PRODUCTS PVT. LT.,
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