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HomeProduct name listsulfoxone

sulfoxone

sulfoxone Structural

What is sulfoxone?

Absorption

Rapidly absorbed.

Toxicity

Oral, rat LD50: 7000 mg/kg

Background

Sulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.

Indications

For the treatment of leprosy and dermatitis herpetiformis

Definition

ChEBI: Aldesulfone is a sulfonamide.

Pharmacokinetics

Sulfoxone is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Metabolism

Hepatic.

Properties of sulfoxone

Boiling point: 857.3±75.0 °C(Predicted)
Density  1.753±0.06 g/cm3(Predicted)
pka 2.58±0.10(Predicted)

Safety information for sulfoxone

Computed Descriptors for sulfoxone

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