Sulfobromophthalein sodium
- CAS NO.：123359-42-2
- Empirical Formula: C20H13Br4NaO11S2
- Molecular Weight: 836.04
- MDL number: MFCD00012442
- EINECS: 626-376-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is Sulfobromophthalein sodium?
Description
A blue dye used in the assessment of hepatobiliary dysfunction. The concentration in plasma is monitored since dye removal from the blood is delayed in hepatic dysfunction. Experimentally the appearance of sulfobromphthalein in the bile can also be measured.
Chemical properties
White, crystalline powder; odorless; bit- ter taste. Hygroscopic; soluble in water; insoluble in alcohol and acetone.
The Uses of Sulfobromophthalein sodium
Medicine (diagnostic aid).
The Uses of Sulfobromophthalein sodium
Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.
Biochem/physiol Actions
Sulfobromophthalein (BSP) is a high affinity organic ion substrate for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.
Properties of Sulfobromophthalein sodium
| Melting point: | >235°C (dec.) |
| storage temp. | room temp |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Crystalline Powder |
| color | White |
| CAS DataBase Reference | 123359-42-2(CAS DataBase Reference) |
Safety information for Sulfobromophthalein sodium
| Signal word | Danger |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for Sulfobromophthalein sodium
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