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HomeProduct name listSulfobromophthalein sodium

Sulfobromophthalein sodium

  • CAS NO.:123359-42-2
  • Empirical Formula: C20H13Br4NaO11S2
  • Molecular Weight: 836.04
  • MDL number: MFCD00012442
  • EINECS: 626-376-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Sulfobromophthalein sodium Structural

What is Sulfobromophthalein sodium?

Description

A blue dye used in the assessment of hepatobiliary dysfunction. The concentration in plasma is monitored since dye removal from the blood is delayed in hepatic dysfunction. Experimentally the appearance of sulfobromphthalein in the bile can also be measured.

Chemical properties

White, crystalline powder; odorless; bit- ter taste. Hygroscopic; soluble in water; insoluble in alcohol and acetone.

The Uses of Sulfobromophthalein sodium

Medicine (diagnostic aid).

The Uses of Sulfobromophthalein sodium

Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.

Biochem/physiol Actions

Sulfobromophthalein (BSP) is a high affinity organic ion substrate for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.

Properties of Sulfobromophthalein sodium

Melting point: >235°C (dec.)
storage temp.  room temp
solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form  Crystalline Powder
color  White
CAS DataBase Reference 123359-42-2(CAS DataBase Reference)

Safety information for Sulfobromophthalein sodium

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H334:Sensitisation, respiratory
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Computed Descriptors for Sulfobromophthalein sodium

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