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HomeProduct name listSULFACHLOROPYRIDAZINE

SULFACHLOROPYRIDAZINE

Synonym(s):N1-(6-Chloro-3-pyridazinyl)sulfanilamide;4-Amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide;Sulfachloropyridazine

  • CAS NO.:80-32-0
  • Empirical Formula: C10H9ClN4O2S
  • Molecular Weight: 284.72
  • MDL number: MFCD00057371
  • EINECS: 201-269-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:15:30
SULFACHLOROPYRIDAZINE Structural

What is SULFACHLOROPYRIDAZINE?

Originator

Sonilyn,Mallinckrodt Inc.,US,1962

The Uses of SULFACHLOROPYRIDAZINE

Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs).

What are the applications of Application

Sulfachloropyridazine is a sulfonamide antimicrobial compound

Definition

ChEBI: A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.

Manufacturing Process

1.9 parts of 3,6-dichloropyridazine, 3.4 parts of sulfanilamide, 2.7 parts of potassium carbonate and 1 part of sodium chloride were ground together. The solid mixture was heated with stirring and as the dichloropyridazine and sulfanilamide melted, the mixture became a slurry. When the bath temperature had reached 140°C a sudden evolution of carbon dioxide occurred which lasted about 5 minutes, after which the mixture set in fine granules. When no more carbon dioxide was evolved, heating was stopped and the reaction mixture was heated with sufficient water to dissolve it and the solution allowed to cool. Unreacted sulfanilamide was collected by filtration. Excess dichloropyridazine was removed from the filtrate by extraction with a water immiscible organic solvent such as ether.
The basic solution was chilled and poured into one-half volume of 1:3 acetic acid. Sufficient hydrochloric acid was added to bring the mixture to pH 4. The crude 3-sulfanilamido-6-chloropyridazine which precipitated was purified by solution in 6 parts of 1:100 ammonium hydroxide, charcoal treatment and precipitation by pouring of the filtrate into dilute acetic acid.

brand name

Nefrosul (3M Pharmaceuticals); Sonilyn,(Carter-Wallace); Vetisulid [Veterinary] (Fort Dodge Animal Health).

Therapeutic Function

Antibacterial

Properties of SULFACHLOROPYRIDAZINE

Melting point: 186-187℃
Boiling point: 559.7±60.0 °C(Predicted)
Density  1.588
refractive index  1.6300 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  0.5 M NaOH: soluble50mg/mL
pka pKa 6.10 (Uncertain)
form  powder
color  off-white to light yellow
BRN  261558
EPA Substance Registry System Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)- (80-32-0)

Safety information for SULFACHLOROPYRIDAZINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H317:Sensitisation, Skin
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for SULFACHLOROPYRIDAZINE

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