SULFACHLOROPYRIDAZINE
Synonym(s):N1-(6-Chloro-3-pyridazinyl)sulfanilamide;4-Amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide;Sulfachloropyridazine
- CAS NO.:80-32-0
- Empirical Formula: C10H9ClN4O2S
- Molecular Weight: 284.72
- MDL number: MFCD00057371
- EINECS: 201-269-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-03 12:01:51
What is SULFACHLOROPYRIDAZINE?
Originator
Sonilyn,Mallinckrodt Inc.,US,1962
The Uses of SULFACHLOROPYRIDAZINE
Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs).
What are the applications of Application
Sulfachloropyridazine is a sulfonamide antimicrobial compound
Definition
ChEBI: A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.
Manufacturing Process
1.9 parts of 3,6-dichloropyridazine, 3.4 parts of sulfanilamide, 2.7 parts of
potassium carbonate and 1 part of sodium chloride were ground together. The
solid mixture was heated with stirring and as the dichloropyridazine and
sulfanilamide melted, the mixture became a slurry. When the bath
temperature had reached 140°C a sudden evolution of carbon dioxide
occurred which lasted about 5 minutes, after which the mixture set in fine
granules. When no more carbon dioxide was evolved, heating was stopped
and the reaction mixture was heated with sufficient water to dissolve it and
the solution allowed to cool. Unreacted sulfanilamide was collected by
filtration. Excess dichloropyridazine was removed from the filtrate by
extraction with a water immiscible organic solvent such as ether.
The basic solution was chilled and poured into one-half volume of 1:3 acetic
acid. Sufficient hydrochloric acid was added to bring the mixture to pH 4. The
crude 3-sulfanilamido-6-chloropyridazine which precipitated was purified by
solution in 6 parts of 1:100 ammonium hydroxide, charcoal treatment and
precipitation by pouring of the filtrate into dilute acetic acid.
brand name
Nefrosul (3M Pharmaceuticals); Sonilyn,(Carter-Wallace); Vetisulid [Veterinary] (Fort Dodge Animal Health).
Therapeutic Function
Antibacterial
Properties of SULFACHLOROPYRIDAZINE
Melting point: | 186-187℃ |
Boiling point: | 559.7±60.0 °C(Predicted) |
Density | 1.588 |
refractive index | 1.6300 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | 0.5 M NaOH: soluble50mg/mL |
pka | pKa 6.10 (Uncertain) |
form | powder |
color | off-white to light yellow |
BRN | 261558 |
EPA Substance Registry System | Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)- (80-32-0) |
Safety information for SULFACHLOROPYRIDAZINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H317:Sensitisation, Skin |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for SULFACHLOROPYRIDAZINE
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