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HomeProduct name listSulbenicillin sodium

Sulbenicillin sodium

  • CAS NO.:28002-18-8
  • Empirical Formula: C16H16N2Na2O7S2
  • Molecular Weight: 458.42
  • MDL number: MFCD01682086
  • EINECS: 248-769-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
Sulbenicillin sodium Structural

What is Sulbenicillin sodium?

Originator

Lillacillin,Takeda,Japan,1973

Definition

ChEBI: Sulbenicillin disodium is an organic sodium salt. It contains a sulbenicillin(2-).

Manufacturing Process

To a suspension of 1.08 parts by weight of 6-aminopenicillanic acid in 8 parts by volume of water is added 1.48 parts by weight of sodium bicarbonate. After the mixture is dissolved, a solution of 1.18 parts by weight of α-sulfophenylacetyl chloride in 10 parts by volume of diethylether is gradually added thereto. The mixture is stirred at a temperature in the neighborhood of 0°C for 1 hour. The aqueous layer is washed twice with 10 parts by volume of portions of ether and adjusted to pH 1.2 with cation exchange resin of polystyrene sulfonic acid type under constant cooling. Then the solution is washed twice with 15 parts by volume of portions of ethyl acetate, followed by extraction twice with 15 parts by volume of portions of n-butanol. The extracts are combined and washed twice with 15 parts by volume of portions of water and, then, extracted with an aqueous solution of sodium bicarbonate. The extract is adjusted to pH 6.5, washed with ether and lyophilized to give the sodium salt of α-sulfobenzylpenicillin. Yield is 1.2 parts by weight.

Therapeutic Function

Antibacterial

Properties of Sulbenicillin sodium

storage temp.  Inert atmosphere,Room Temperature
form  Solid
color  White to off-white
Water Solubility  Water: 250 mg/mL (545.35 mM)
CAS DataBase Reference 28002-18-8(CAS DataBase Reference)

Safety information for Sulbenicillin sodium

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Sulbenicillin sodium

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