Sulbenicillin sodium
- CAS NO.:28002-18-8
- Empirical Formula: C16H16N2Na2O7S2
- Molecular Weight: 458.42
- MDL number: MFCD01682086
- EINECS: 248-769-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Sulbenicillin sodium?
Originator
Lillacillin,Takeda,Japan,1973
Definition
ChEBI: Sulbenicillin disodium is an organic sodium salt. It contains a sulbenicillin(2-).
Manufacturing Process
To a suspension of 1.08 parts by weight of 6-aminopenicillanic acid in 8 parts by volume of water is added 1.48 parts by weight of sodium bicarbonate. After the mixture is dissolved, a solution of 1.18 parts by weight of α-sulfophenylacetyl chloride in 10 parts by volume of diethylether is gradually added thereto. The mixture is stirred at a temperature in the neighborhood of 0°C for 1 hour. The aqueous layer is washed twice with 10 parts by volume of portions of ether and adjusted to pH 1.2 with cation exchange resin of polystyrene sulfonic acid type under constant cooling. Then the solution is washed twice with 15 parts by volume of portions of ethyl acetate, followed by extraction twice with 15 parts by volume of portions of n-butanol. The extracts are combined and washed twice with 15 parts by volume of portions of water and, then, extracted with an aqueous solution of sodium bicarbonate. The extract is adjusted to pH 6.5, washed with ether and lyophilized to give the sodium salt of α-sulfobenzylpenicillin. Yield is 1.2 parts by weight.
Therapeutic Function
Antibacterial
Properties of Sulbenicillin sodium
storage temp. | Inert atmosphere,Room Temperature |
form | Solid |
color | White to off-white |
Water Solubility | Water: 250 mg/mL (545.35 mM) |
CAS DataBase Reference | 28002-18-8(CAS DataBase Reference) |
Safety information for Sulbenicillin sodium
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Sulbenicillin sodium
Abamectin manufacturer
AKASH PHARMA EXPORTS
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