Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listSodium Stearyl Fumarate

Sodium Stearyl Fumarate

Synonym(s):(E)-2-Butenedioic acid monooctadecyl ester sodium salt;Sodium octadecyl fumarate;Sodium stearyl fumarate

  • CAS NO.:4070-80-8
  • Empirical Formula: C22H41NaO4
  • Molecular Weight: 392.56
  • MDL number: MFCD07782099
  • EINECS: 223-781-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
Sodium Stearyl Fumarate Structural

What is Sodium Stearyl Fumarate?

Description

Sodium Stearyl Fumarate (SSF) is used as a lubricant in tableting to reduce the friction between the tablet and the die wall and to prevent adhesion of the material to punches or the die wall in the pharmaceutical industries. It is used also as a lubricant in the manufacturing of capsules and other oral dosage forms. Sodium stearyl fumarate is also used in food production as a dough conditioner, a conditioning agent, and a stabilizing agent.

Chemical properties

White or off-white crystalline powder

Chemical properties

Sodium stearyl fumarate is a fine, white powder with agglomerates of flat, circular-shaped particles.

The Uses of Sodium Stearyl Fumarate

Sodium Stearyl Fumarate is a dough conditioner and conditioning agent that is a white powder practically insoluble in water. It is used as a dough conditioner in yeast-raised baked goods. It is used as a conditioning agent in dehydrated potatoes. It also functions as a maturing and bleaching agent.

The Uses of Sodium Stearyl Fumarate

cationic transfection agent, bile acid sequestrant, vaccine adjuvant, protein stabilizer

The Uses of Sodium Stearyl Fumarate

Binder

Production Methods

Stearyl alcohol is reacted with maleic anhydride. The product of this reaction then undergoes an isomerization step followed by salt formation to produce sodium stearyl fumarate.

Pharmaceutical Applications

Sodium stearyl fumarate is used as a lubricant in capsule and tablet formulations at 0.5–2.0% w/w concentration. It is also used in certain food applications.

Safety

Sodium stearyl fumarate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material.
Metabolic studies of sodium stearyl fumarate in the rat and dog indicated that approximately 80% was absorbed and 35% was rapidly metabolized. The fraction absorbed was hydrolyzed to stearyl alcohol and fumaric acid, with the stearyl alcohol further oxidized to stearic acid. In the dog, sodium stearyl fumarate that was not absorbed was excreted unchanged in the feces within 24 hours.
Stearyl alcohol and stearic acid are naturally occurring constituents in various food products, while fumaric acid is a normal constituent of body tissue. Stearates and stearyl citrate have been reviewed by the WHO and an acceptable daily intake for stearyl citrate has been set at up to 50 mg/kg body-weight. The establishment of an acceptable daily intake for stearates and fumaric acid was thought unnecessary.
Disodium fumarate has been reported to have a toxicity not greatly exceeding that of sodium chloride.

storage

At ambient temperature, sodium stearyl fumarate is stable for up to 3 years when stored in amber glass bottles with polyethylene screw caps.
The bulk material should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Sodium stearyl fumarate is reported to be incompatible with chlorhexidine acetate.

Regulatory Status

GRAS listed. Permitted by the FDA for direct addition to food for human consumption as a conditioning or stabilizing agent in various bakery products, flour-thickened foods, dehydrated potatoes, and processed cereals up to 0.2–1.0% by weight of the food. Included in nonparenteral medicines licensed in the UK. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

References

[1] Arne W. Hölzer and John Sjögren, Evaluation of sodium stearyl fumarate as a tablet lubricant, International Journal of Pharmaceutics, 1979, vol. 2, 145-153
[2] Holger Zorn and Peter Czermak, Biotechnology of Food and Feed Additives, 2014
[3] https://www.fda.gov

Properties of Sodium Stearyl Fumarate

Melting point: >196°C (dec.)
storage temp.  Inert atmosphere,Room Temperature
solubility  Practically insoluble in water, slightly soluble in methanol, practically insoluble in acetone and in anhydrous ethanol.
form  neat
form  Solid
color  White to Off-White

Safety information for Sodium Stearyl Fumarate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Sodium Stearyl Fumarate

InChIKey GKCVIRALYIXVLE-RZLHGTIFSA-M

Abamectin manufacturer

Dayaram Pharma Chem

1Y
Phone:+91-9601766800
Whatsapp: +91 9601766800
product: 4070-80-8 Sodium stearyl fumarate 98%
Inquiry

Panvo Organics Pvt Ltd

1Y
Phone:+91-9789806833
Whatsapp: +91 9789806833
product: 4070-80-8 99%
Inquiry

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: Sodium stearyl fumarate 98%
Inquiry

Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: Sodium stearyl fumarate 4070-80-8 98%
Inquiry

Nitika Pharmaceutical Specialities Pvt Ltd

1Y
Phone:+91-8956932443
Whatsapp: +91-8956932443
product: 4070-80-8 Sodium stearyl fumarate 98%
Inquiry

Prachin Chemical

1Y
Phone:+91-9825015645
Whatsapp: +91- 9825015645
product: 4070-80-8 98%
Inquiry

Gloria Interchem Pvt Ltd

1Y
Phone:+91-9825029521
Whatsapp: +91-9825029521
product: Sodium stearyl fumarate 99%
Inquiry

Nivedita Chemicals Pvt Ltd (Anek Prayog Pvt Ltd)

1Y
Phone:+912228327321
Whatsapp: +91-22-28327321
product: Sodium stearyl fumarate 4070-80-8 98%
Inquiry

Shreyaa Medilife Private Limited

1Y
Phone:+919879513108
Whatsapp: +91-9879513108
product: 4070-80-8 Sodium stearyl fumarate 98%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.