2,4,5-TRIFLUOROBENZYL CHLORIDE
- CAS NO.：243139-71-1
- Empirical Formula: C7H4ClF3
- Molecular Weight: 180.55
- MDL number: MFCD00236319
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-11 16:58:07
What is 2,4,5-TRIFLUOROBENZYL CHLORIDE?
Chemical properties
Colorless to Almost colorless clear liquid.
The Uses of 2,4,5-TRIFLUOROBENZYL CHLORIDE
2,4,5-Trifluorobenzyl chloride is a useful research chemical.
The Uses of 2,4,5-TRIFLUOROBENZYL CHLORIDE
2,4,5-Trifluorobenzyl chloride is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor that decreases in glucagon to improve control of blood sugar used for the treatment of type 1 diabetes, 79% of the dose excreted in the urine.
Synthesis
On the four-neck flask, install a stirrer, a thermometer, a chlorine gas pipe and a reflux condenser. The reflux condenser is connected to the HCl absorption system, and a light source is installed near the flask.Add 146.0g 2,4,5-trifluorotoluene and 3.0g azobisisobutyronitrile into the reaction flask, stir and heat, and when the temperature rises to 110°C, add dry chlorine gas, and Using GC tracking, after about 3h of chlorine gas, stop the halogenating agent chlorine gas, cool the reactant, wash it with water to neutrality, dry and distill under reduced pressure to obtain 2,4,5-trifluorobenzyl chloride.
Properties of 2,4,5-TRIFLUOROBENZYL CHLORIDE
| Boiling point: | 175℃ |
| Density | 1,689 g/cm3 |
| refractive index | 1.5050 |
| Flash point: | 65°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | clear liquid |
| color | Colorless to Almost colorless |
| CAS DataBase Reference | 243139-71-1(CAS DataBase Reference) |
Safety information for 2,4,5-TRIFLUOROBENZYL CHLORIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H227:Flammable liquids H290:Corrosive to Metals H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P390:Absorb spillage to prevent material damage. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for 2,4,5-TRIFLUOROBENZYL CHLORIDE
New Products
Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2,2-Difluoropropylamine hydrochloride tert-butyl 3-bromoazetidine-1-carboxylate (R)-1-Boc-3-hydroxypyrrolidine DIFLUOROACETIC ANHYDRIDE 2,2-Difluoropropionic acid Diallylamine, 99% Calcium hydroxide, 95% Aluminum oxide, basic 2-Bromophenylacetonitrile, 97% L-tert-Leucine,97% N-Hydroxy-2-methylpropanimidamide 4-(3,4-Dichlorophenyl)-3,4-Dihydro-N-Methyl-1-(2H)-Naphthalenimine (Schiff Base) 2-AMINO-3,5-DIBROMO BENZALDEHYDE [ADBA] L-Glutamic Acid Dimethyl Ester Hcl 10-Methoxy-5H-dibenz[b,f]azepine 5-Cyanophthalide N, N-Carbonyldiimidazole (CDI) Dibenzoyl Peroxide Titanium Dioxide 2-(Methylthio) Benzonitrile Sodium Acetate Anhydrous Allopurinol 1,5-DibromopentaneRelated products of tetrahydrofuran
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