Sodium nitrite
Synonym(s):Sodium Nitrite;Sodium nitrite solution;Anti-Rust;Diazotizing salts;Nitrite standard for aqueous matrices ready foruse
- CAS NO.:7632-00-0
- Empirical Formula: NaNO2
- Molecular Weight: 69
- MDL number: MFCD00011118
- EINECS: 231-555-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-23 11:11:07
What is Sodium nitrite?
Description
Sodium nitrite is similar in name and use to sodium nitrate. Both are preservatives used in processed meats, such as salami, hot dogs, and bacon. Sodium nitrite has been synthesized by several chemical reactions that involve the reduction of sodium nitrate. Industrial production of sodium nitrite is primarily by the absorption of nitrogen oxides into aqueous sodium carbonate or sodium hydroxide. Over the years, sodium nitrite has raised some concerns about its safety in foods, but it remains in use and there are indications that it may actually be healthy. Sodium nitrite was developed during the 1960s. In 1977, the US Department of Agriculture (USDA) considered banning it but the USDA’s final ruling on the additive came out in 1984, allowing its use. Studies in the 1990s indicated some adverse effects of sodium nitrite, for instance the potential to cause childhood leukemia and brain cancers. In the late 1990s, the National Toxicity Program (NTP) began a review of sodium nitrite and proposed listing sodium nitrite as a developmental and reproductive toxicant, but a report in 2000 by NTP proposed that sodium nitrite is not a toxic substance and removed it from the list of developmental and reproductive toxicants. It is now believed that it can help with organ transplants and leg vascular problems, while preventing heart attacks and sickle cell disease.
The Uses of Sodium nitrite
Sodium nitrite is used to fix the colors in preserved fish and meats. It is also important(along with sodium chloride) in controlling the bacterium Clostridium botulinum, which causes botulism. Lunch meats, hams, sausages, hot dogs, and bacon are usually preserved this way.
In medicines, it is a vasodilator, intestinal relaxant, bronchodilator, and an antidote to cyanide and hydrogen sulfide poisoning.
Sodium nitrite is produced in the human body by the action of saliva on sodium nitrate, and is important in controlling bacteria in the stomach, to prevent gastroenteritis. The body produces more sodium nitrite than is consumed in food.
Sodium nitrite can react with proteins in the stomach or during cooking, especially in high heat (such as frying bacon), to form carcinogenic N-nitrosamines.To prevent this, ascorbic acid or erythorbic acid is commonly added to cured meats.
manufacture of diazo dyes, nitroso Compounds, and in many other processes of manufacture of organic chemicals; dyeing and printing textile fabrics; bleaching flax, silk, and linen.
The Uses of Sodium nitrite
To ACN (350 mL) at RT was added CuBr2 (67 g, 300 mmol). The mixture was cooled to 0-5 C and was treated dropwise with t-BuONO (72.5 mL, 535 mmol). The mixture was stirred for 5 min, then was added the SM (35 g, 238 mmol). The reaction was stirred at RT for 2 h. EtOAc (525 mL) was added to the mixture and the reaction was quenched with 10% aq NH4Cl (350 mL) and 2% aq NH3 (175 mL). The layers were separated and the aq layer was extracted with EtOAc. The combined organics were dried and concentrated. The resulting material was purified by silica gel chromatography (eluting with 5% EtOAc/hexane) to provide the product as a yellow solid. [35 g, 70%]
What are the applications of Application
Sodium nitrite is a strong oxidizer but stable under ordinary conditions of use and storage
Properties of Sodium nitrite
Melting point: | 271 °C (lit.) |
Boiling point: | 320 °C |
Density | 2.17g/cm3 |
storage temp. | 2-8°C |
solubility | aqueous acid: 1 - 2μl acetic acid per ml H2Osoluble |
form | powder |
appearance | White to slightly yellow solid |
color | White or colorless |
Odor | Odorless |
Water Solubility | 820 g/L (20 ºC) |
Sensitive | Hygroscopic |
Safety information for Sodium nitrite
Signal word | Danger |
Pictogram(s) |
Flame Over Circle Oxidizers GHS03 Skull and Crossbones Acute Toxicity GHS06 Environment GHS09 |
GHS Hazard Statements |
H272:Oxidising liquids;Oxidising solids H301:Acute toxicity,oral H319:Serious eye damage/eye irritation H400:Hazardous to the aquatic environment, acute hazard |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P220:Keep/Store away from clothing/…/combustible materials. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Sodium nitrite
InChIKey | LPXPTNMVRIOKMN-UHFFFAOYSA-M |
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