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HomeProduct name listSNAP

SNAP

Synonym(s):(±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem;SNAP

SNAP Structural

What is SNAP?

Chemical properties

Green Crystalline Solid

The Uses of SNAP

The D-isomer of SNAP. Serves as an NO donor

The Uses of SNAP

The D-isomer of SNAP. Serves as an NO donor.

What are the applications of Application

(±)-S-Nitroso-N-acetylpenicillamine is a cysteine protease inhibitor and spontaneous NO donor in physiological conditions

Definition

ChEBI: A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.

General Description

Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.

Biological Activity

A stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t ?of 37h.

Biochem/physiol Actions

EC50 = 130 nM in relaxation of isolated bovine coronary artery rings

storage

Store at -20°C

Properties of SNAP

Density  1.36±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  H2O: ≥2 mg/mL
form  powder
pka 3.06±0.10(Predicted)
color  green

Safety information for SNAP

Computed Descriptors for SNAP

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