SNAP
Synonym(s):(±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem;SNAP
- CAS NO.：79032-48-7
- Empirical Formula: C7H12N2O4S
- Molecular Weight: 220.25
- MDL number: MFCD00153852
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is SNAP?
Chemical properties
Green Crystalline Solid
The Uses of SNAP
The D-isomer of SNAP. Serves as an NO donor
The Uses of SNAP
The D-isomer of SNAP. Serves as an NO donor.
What are the applications of Application
(±)-S-Nitroso-N-acetylpenicillamine is a cysteine protease inhibitor and spontaneous NO donor in physiological conditions
Definition
ChEBI: A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.
General Description
Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
Biological Activity
A stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t ?of 37h.
Biochem/physiol Actions
EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
storage
Store at -20°C
Properties of SNAP
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | H2O: ≥2 mg/mL |
| form | powder |
| pka | 3.06±0.10(Predicted) |
| color | green |
Safety information for SNAP
Computed Descriptors for SNAP
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin E Tubulysin F Tubulysin B Diethyl Aluminium Cyanide (1.0 M in Toluene) 4,4-DIFLUOROPIPERIDINE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2,2-Difluoropropylamine hydrochloride Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateRelated products of tetrahydrofuran
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