Sancycline
- CAS NO.:808-26-4
- Empirical Formula: C21H22N2O7
- Molecular Weight: 414.41
- MDL number: MFCD00864992
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is Sancycline?
Description
Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.
Chemical properties
Yellow Solid
The Uses of Sancycline
Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.
The Uses of Sancycline
A semi-synthetic antibiotic related to tetracycline
The Uses of Sancycline
Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR).
What are the applications of Application
Sancycline is a rare semi-synthetic tetracycline
Definition
ChEBI: Sancycline is a member of tetracyclines.
brand name
Bonomycin (Pfizer).
Properties of Sancycline
Melting point: | 224-2280C (dec) |
Boiling point: | 750.9±60.0 °C(Predicted) |
Density | 1.61±0.1 g/cm3(Predicted) |
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly), Water (Slig |
form | Solid |
pka | 4.50±1.00(Predicted) |
color | Beige to Dark Beige |
Stability: | Hygroscopic |
CAS DataBase Reference | 808-26-4 |
Safety information for Sancycline
Computed Descriptors for Sancycline
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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