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HomeProduct name listSancycline

Sancycline

  • CAS NO.:808-26-4
  • Empirical Formula: C21H22N2O7
  • Molecular Weight: 414.41
  • MDL number: MFCD00864992
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Sancycline Structural

What is Sancycline?

Description

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

Chemical properties

Yellow Solid

The Uses of Sancycline

Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

The Uses of Sancycline

A semi-synthetic antibiotic related to tetracycline

The Uses of Sancycline

Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR).

What are the applications of Application

Sancycline is a rare semi-synthetic tetracycline

Definition

ChEBI: Sancycline is a member of tetracyclines.

brand name

Bonomycin (Pfizer).

Properties of Sancycline

Melting point: 224-2280C (dec)
Boiling point: 750.9±60.0 °C(Predicted)
Density  1.61±0.1 g/cm3(Predicted)
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly), Water (Slig
form  Solid
pka 4.50±1.00(Predicted)
color  Beige to Dark Beige
Stability: Hygroscopic
CAS DataBase Reference 808-26-4

Safety information for Sancycline

Computed Descriptors for Sancycline

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