Deslanoside

Synonym(s):Deacetyllanatoside C;Desacetyllanatoside C

CAS NO.：17598-65-1
Empirical Formula: C47H74O19
Molecular Weight: 943.08
MDL number: MFCD00135818
EINECS: 241-568-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:14

What is Deslanoside?

Absorption

Little absorption from the gastrointestinal tract (40%).

Toxicity

Symptoms of overdose include ventricular tachycardia, ventricular fibrillation, progressive bradyarrhythmias, or heart block.

Chemical properties

Solution S is clear (2.2.1) and colourless (2.2.2, Method II).

The Uses of Deslanoside

Cardiotonic.

Indications

For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.

Background

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.

Definition

ChEBI: A cardenolide glycoside that is lanatoside C with the acetoxy group replaced by a hydroxy group.

brand name

Cedilanid-D (Novartis).

Pharmacokinetics

Deslanoside is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

Metabolism

Not Available

Properties of Deslanoside

Melting point:	220-235°C
alpha	D20 +12° (c = 1.084 in 75% alc)
Boiling point:	732.1°C (rough estimate)
Density	1.1255 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	2-8°C
solubility	DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
form	Solid
pka	12.89±0.70(Predicted)
form	neat
color	White to off-white
CAS DataBase Reference	17598-65-1(CAS DataBase Reference)

Safety information for Deslanoside

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P314:Get medical advice/attention if you feel unwell. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.