S- (+)-Rolipram
- CAS NO.：85416-73-5
- Empirical Formula: C16H21NO3
- Molecular Weight: 275.34
- MDL number: MFCD03093861
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is S- (+)-Rolipram?
The Uses of S- (+)-Rolipram
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer
The Uses of S- (+)-Rolipram
S-(+)-Rolipram is an inhibitor of cyclic AMP-specific phosphodiesterase. It is the S isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor
What are the applications of Application
S-(+)-Rolipram is an inhibitor of cyclic AMP-specific phosphodiesterase
Definition
ChEBI: The (S)-enantiomer of rolipram.
Biological Activity
Less active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ).
storage
Room temperature
Properties of S- (+)-Rolipram
| Melting point: | 133-136℃ |
| Density | 1.155 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO : 100 mg/mL (363.19 mM; Need ultrasonic) |
| form | White to off-white solid. |
| color | White to Almost white |
Safety information for S- (+)-Rolipram
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for S- (+)-Rolipram
New Products
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