Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listVinpocetine

Vinpocetine

Synonym(s):(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester;Eburnamenine-14-carboxylic acid ethyl ester

  • CAS NO.:42971-09-5
  • Empirical Formula: C22H26N2O2
  • Molecular Weight: 350.46
  • MDL number: MFCD00211233
  • EINECS: 256-028-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-03 16:17:04
Vinpocetine Structural

What is Vinpocetine?

Description

Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1?Also blocks voltage-gated Na+?channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity.2?It reduces inflammatory IL-1β and TNF-α expression in rat hippocampus.3?Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury.4?Vinpocetine exerts neuroprotective effects by suppressing microglial inflammation.5

Description

Vinpocetine is a derivative of the alkaloid vincamine that has vasodilating properties. C. Szántay isolated it from the periwinkle plant (Vinca minor) in 1975, but that was 2 years after C. L?rincz and co-inventors patented its synthesis.
Vinpocetine is used in eastern Europe to treat cerebral vascular disorders and memory impairment. It is not approved for drug use in the United States, but can be sold over the counter as a dietary supplement. Some body builders use it as a vasodilator to improve performance, but no studies have been performed to establish its effectiveness.
?

Chemical properties

White Crystalline Solid

The Uses of Vinpocetine

A calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) inhibitor

The Uses of Vinpocetine

A derivative of Vincamine with vasodilating activity. Vasodilator (cerebral).

The Uses of Vinpocetine

calcium regulator

The Uses of Vinpocetine

Gleevec metabolite, tyrosine kinase inhibitor

What are the applications of Application

Vinpocetine is an inhibitor of Ca2+/CaM-PDE with neuroprotective properties

Definition

ChEBI: Vinpocetine is an alkaloid. It has a role as a geroprotector.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE1 (IC 50 = 21 μ M). Also blocks voltage-gated Na + channels.

Biochem/physiol Actions

Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.

References

1) Hagiwara?et al. (1984),?Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle; Biochem. Pharmacol.,?33?453 2) Molnar and Erdo (1995),?Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons; Eur. J. Pharmacol.,?273?303 3) Gomez?et al. (2014),?The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduced inflammatory IL1β and TNF-α expression in rat hippocampus; J. Neurochem.,?130?770 4) Wang?et al. (2014),?Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury; Neuro. Sci. Lett.,?566?247 5) Zhao?et al.?(2011), TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation; Glia Biol.,?7?187

Properties of Vinpocetine

Melting point: 147-153 °C dec.
Boiling point: 484.44°C (rough estimate)
alpha  D20 +114° (c = 1 in pyridine)
Density  1.1260 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  DMSO: 5 mg/mL
form  solid
pka 7.87±0.60(Predicted)
color  white
optical activity [α]/D 148.5±5.0°, c = 0.1 in chloroform
λmax 315nm(EtOH)(lit.)
Merck  14,9991
Stability: Photosensitive
NIST Chemistry Reference Vinpocetine(42971-09-5)

Safety information for Vinpocetine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for Vinpocetine

InChIKey DDNCQMVWWZOMLN-IRLDBZIGSA-N

Vinpocetine manufacturer

Afton Pharma

1Y
Phone:+919712000202
Whatsapp: +91-9712000202
product: 42971-09-5 / 80038-06-8 Vinpocetine 98%
Inquiry

Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: 42971-09-5 / 80038-06-8 98%
Inquiry

Ennature Biopharma (A Division of India Glycols Limited)

1Y
Phone:+919311507878
Whatsapp: +91-9311507878
product: Vinpocetine 98%
Inquiry

Quad Lifesciences Pvt Ltd

1Y
Phone:+91-9810034045
Whatsapp: +91-9810034045
product: Vinpocetine 42971-09-5 / 80038-06-8 99%
Inquiry

Chemical Resources

1Y
Phone:+91-1725022460
product: 42971-09-5 / 80038-06-8 Vinpocetine 99%
Inquiry

Pharma Links

Maharashtra
Phone:91-9619854045
Whatsapp: 91-9619854045
product: Vinpocetine
Inquiry

Festiva Pharma

Gujarat
Phone:91-9033667967
Whatsapp: 91-9033667967
product: Vinpocetine
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.