RO 20-1724
Synonym(s):4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone;Ro 20-1724;Ro-20-1724 - CAS 29925-17-5 - Calbiochem
- CAS NO.:29925-17-5
- Empirical Formula: C15H22N2O3
- Molecular Weight: 278.35
- MDL number: MFCD00077397
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is RO 20-1724?
Description
RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
The Uses of RO 20-1724
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.
The Uses of RO 20-1724
Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.
What are the applications of Application
Ro 20-1724 is a selective inhibitor of cAMP-specific phosphodiesterase
Definition
ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.
Biological Activity
Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions
Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.
storage
Store at RT
References
1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19
Properties of RO 20-1724
Boiling point: | 483.8±25.0 °C(Predicted) |
Density | 1.099±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | ethanol: 7 mg/mL |
form | solid |
pka | 14.54±0.40(Predicted) |
color | White |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months. |
CAS DataBase Reference | 29925-17-5(CAS DataBase Reference) |
Safety information for RO 20-1724
Computed Descriptors for RO 20-1724
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