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HomeProduct name listRO 20-1724

RO 20-1724

Synonym(s):4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone;Ro 20-1724;Ro-20-1724 - CAS 29925-17-5 - Calbiochem

RO 20-1724 Structural

What is RO 20-1724?

Description

RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable

The Uses of RO 20-1724

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.

The Uses of RO 20-1724

Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.

What are the applications of Application

Ro 20-1724 is a selective inhibitor of cAMP-specific phosphodiesterase

Definition

ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.

Biological Activity

Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Biochem/physiol Actions

Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.

storage

Store at RT

References

1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19

Properties of RO 20-1724

Boiling point: 483.8±25.0 °C(Predicted)
Density  1.099±0.06 g/cm3(Predicted)
storage temp.  room temp
solubility  ethanol: 7 mg/mL
form  solid
pka 14.54±0.40(Predicted)
color  White
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
CAS DataBase Reference 29925-17-5(CAS DataBase Reference)

Safety information for RO 20-1724

Computed Descriptors for RO 20-1724

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