S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

CAS NO.：37686-84-3
Empirical Formula: C20H28N4O
Molecular Weight: 340.46
MDL number: MFCD00242729
EINECS: 253-624-2
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:38

What is S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA?

Description

Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys.1?Partial agonist at recruitment of β-arrestin2 to the D2 receptor.2 Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.3

The Uses of S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent.

Definition

ChEBI: Terguride is an organic molecular entity.

References

1) Akai et al. (1993), Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys; Ann. Neurol., 133 507 2) Klewe et al. (2008), Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling; Neuropharmacology, 54 1215 3) Dumitrascu et al. (2011), Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats; Eur. Respir. J., 37 1104

Properties of S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

Melting point:	203-204° (dec); mp 205-207° (dec) (Cerny)
Boiling point:	476.25°C (rough estimate)
alpha	D20 +30° (c = 1 in pyridine); D20 +29.0° (c = 0.2 in pyridine)
Density	1.1056 (rough estimate)
refractive index	1.6620 (estimate)
storage temp.	2-8°C
solubility	DMSO: soluble
form	solid
pka	13.60±0.20(Predicted)
color	white
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.