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HomeProduct name listS-ADENOSYL-L-METHIONINE CHLORIDE SALT

S-ADENOSYL-L-METHIONINE CHLORIDE SALT

  • CAS NO.:24346-00-7
  • Empirical Formula: C15H23ClN6O5S
  • Molecular Weight: 434.9
  • MDL number: MFCD00036337
  • EINECS: 246-184-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:59
S-ADENOSYL-L-METHIONINE CHLORIDE SALT Structural

What is S-ADENOSYL-L-METHIONINE CHLORIDE SALT?

Purification Methods

Purify it by ion exchange on Amberlite IRC-150 and eluting with 0.1-4M HCl. [Stolowitz & Minch J Am Chem Soc 103 6015 1981.] It has been isolated as the tri-reineckate salt by adding 2volumes of 1% solution of ammonium reineckate in 2% perchloric acid. The reineckate salt separates at once but is kept at 2o overnight. The salt is collected on a sintered glass funnel, washed with 0.5% of ammonium reineckate, dried (all operations at 2o) and stored at 2o. To obtain adenosylmethionine, the reineckate is dissolved in a small volume of methyl ethyl ketone (MEK) and centrifuged at room temperature to remove a small amount of solid. The clear dark red supernatant is extracted (in a separating funnel) with a slight excess of 0.1N H2SO4. The aqueous phase is re-extracted with fresh MEK until it is colourless. [Note that reineckates have UV absorption at 305nm ( 15,000), and the optical density at 305nm is used to detect and estimate reineckate ions.] MEK is removed from the aqueous layer containing adenosylmethionine sulfate; the pH is adjusted to 5.6-6.0 and extracted with two volumes of Et2O. The sulfate is obtained by evaporating the aqueous layer in vacuo. The hydrochloride can be obtained in the same way but using HCl instead of H2SO4. SAM-HCl has a solubility of 10% in H2O. The salts are stable in the cold at pH 4-6 but decompose in alkaline media. [Cantoni Biochemical Preparations 5 58 1957.] The purity of SAM can be determined by paper chromatography [Cantoni J Biol Chem 204 403 1953, Methods Enzymol 3 601 1957], electrophoretic methods or enzymic analysis [Cantoni & Vignos J Biol Chem 209 647 1954]. [Beilstein 26 III/IV 3676.]

Properties of S-ADENOSYL-L-METHIONINE CHLORIDE SALT

storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  H2O: 100 mg/mL
form  Solid
color  Off-White to Dark Yellow
Stability: Hygroscopic

Safety information for S-ADENOSYL-L-METHIONINE CHLORIDE SALT

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for S-ADENOSYL-L-METHIONINE CHLORIDE SALT

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