(S)-(-)-2-Methyl-1-butanol
Synonym(s):(S)-(−)-2-Methyl-1-butanol;Active amyl alcohol
- CAS NO.:1565-80-6
- Empirical Formula: C5H12O
- Molecular Weight: 88.15
- MDL number: MFCD00064299
- EINECS: 216-366-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-11-28 16:31:43
What is (S)-(-)-2-Methyl-1-butanol?
Chemical properties
clear colourless liquid
The Uses of (S)-(-)-2-Methyl-1-butanol
(S)-(-)-2-Methylbutanol can be used as a reactant to prepare:
- Methylbutyl-2-(3-thienyl)acetate (MBTA) by esterification reaction with 3-thiophene acetic acid in the presence of an acid catalyst.
- (2S)-2-Methyl-1-butanesulfenyl chloride by reacting with thioacetic acid using Mitsunobu reaction conditions.
- (+)-Violapyrone C and (-)-myxalamide A.
The Uses of (S)-(-)-2-Methyl-1-butanol
(S)-(?)-2-Methylbutanol can be used to prepare:
- (S)-(?)-2-Methyl-1-butyloxy carbonyl amino hexyl isocyanate (MBI), which is used to synthesize isocyanate copolymers.
- Chiral alkoxynaphathoic acid derivatives having liquid crystalline properties.
- 3,4-Bis[(S)-2-methylbutoxy]thiophene, a key intermediate for the synthesis of polythiophenes.
Definition
ChEBI: The (S)-enantiomer of 2-methylbutan-1-ol.
General Description
rest mainly 3-methyl-1-butanol
Purification Methods
Reflux the butanol with CaO, distil, reflux with magnesium and again fractionally distil it. A small sample of highly purified material is obtained by fractional crystallisation after conversion into a suitable ester such as the trinitrophthalate or the 3-nitrophthalate. The latter is converted to the cinchonine salt in acetone and recrystallised from CHCl3 by adding pentane. The salt is saponified, extracted with ether, and fractionally distilled. [Terry et al. J Chem Eng Data 5 403 1960, Beilstein 1 IV 1666.]
Properties of (S)-(-)-2-Methyl-1-butanol
Melting point: | -70 °C |
Boiling point: | 136-138 °C(lit.) |
alpha | -5.8 º (neat 23 ºC) |
Density | 0.811 g/mL at 25 °C(lit.) |
vapor density | 3 (vs air) |
vapor pressure | 1 mm Hg ( 13.6 °C) |
refractive index | n |
Flash point: | 120 °F |
storage temp. | 2-8°C |
solubility | soluble in Chloroform, Ethanol |
pka | 15.24±0.10(Predicted) |
form | clear liquid |
color | Colorless to Almost colorless |
Odor | ethereal fresh |
optical activity | [α]23/D 5.8°, neat |
Water Solubility | 36 g/L (30 ºC) |
Merck | 14,6030 |
BRN | 1718809 |
Dielectric constant | 15.8(20℃) |
CAS DataBase Reference | 1565-80-6(CAS DataBase Reference) |
NIST Chemistry Reference | 1-Butanol, 2-methyl-, (S)-(1565-80-6) |
EPA Substance Registry System | 1-Butanol, 2-methyl-, (2S)- (1565-80-6) |
Safety information for (S)-(-)-2-Methyl-1-butanol
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. |
Computed Descriptors for (S)-(-)-2-Methyl-1-butanol
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