(S)-(-)-2-Azetidinecarboxylic acid
Synonym(s):(S)-Azetidine-2-carboxylic acid
- CAS NO.：2133-34-8
- Empirical Formula: C4H7NO2
- Molecular Weight: 101.1
- MDL number: MFCD00005166
- EINECS: 218-362-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is (S)-(-)-2-Azetidinecarboxylic acid?
Chemical properties
white to light yellow crystal powder
The Uses of (S)-(-)-2-Azetidinecarboxylic acid
(S)-(-)-2-Azetidinecarboxylic acid is a four-membered ring analog of L-Proline, It is a useful intermediate in the synthesis of polypeptides,Used in synthesis of abnormally high molecular weight polypeptides.
The Uses of (S)-(-)-2-Azetidinecarboxylic acid
Specific proline antagonist. Used in synthesis of abnormally high molecular weight polypeptides.
The Uses of (S)-(-)-2-Azetidinecarboxylic acid
L-Azetidine-2-carboxylic acid has been used as a:
- collagen synthesis inhibitor
- protein folding antagonist
- as a standard in liquid chromatography-mass spectrometry
What are the applications of Application
L-Azetidine-2-carboxylic acid is a toxic amino acid, endogenous metabolite, and specific proline antagonist.
Definition
ChEBI: The (S)-enantiomer of azetidine-2-carboxylic acid.
General Description
L-Azetidine-2-carboxylic acid is a non-protein amino acid and teratogenic agent. It is toxic in nature.
Biochem/physiol Actions
Azetidine-2-carboxylic acid (AZC) triggers protein aggregation or upregulates the expression of an aggregation-prone mutant protein, upon interference with nascent protein folding.
Safety Profile
Moderately toxic by subcutaneousroute. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx.
Properties of (S)-(-)-2-Azetidinecarboxylic acid
| Melting point: | ~215 °C (dec.) |
| Boiling point: | 189.47°C (rough estimate) |
| alpha | -125 º (c=1, water 25 ºC) |
| Density | 1.2245 (rough estimate) |
| refractive index | -122 ° (C=4, H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Crystalline Powder or Crystals |
| pka | 2.35±0.20(Predicted) |
| color | White to light beige |
| Water Solubility | 5 g/100 mL |
| Merck | 14,908 |
| BRN | 80678 |
| CAS DataBase Reference | 2133-34-8(CAS DataBase Reference) |
Safety information for (S)-(-)-2-Azetidinecarboxylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-(-)-2-Azetidinecarboxylic acid
| InChIKey | IADUEWIQBXOCDZ-VKHMYHEASA-N |
(S)-(-)-2-Azetidinecarboxylic acid manufacturer
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