RUBOXISTAURIN HYDROCHLORIDE
- CAS NO.：169939-93-9
- Empirical Formula: C28H29ClN4O3
- Molecular Weight: 505.02
- MDL number: MFCD00940226
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-16 15:32:52
What is RUBOXISTAURIN HYDROCHLORIDE?
Description
LY333531 is an inhibitor of PKCβ (IC50s = 4.7 and 5.9 nM for PKCβ1 and PKCβ2, respectively). It is selective for PKCβ1 and PKCβ2 over PKCα, -γ, -δ, -ε, -ζ, and -η (IC50s = 360, 300, 250, >100,000, and 52 nM, respectively). LY333531 also inhibits glycogen synthase kinase 3β (GSK3β; IC50 = 39.4 nM). It inhibits neutrophil extracellular trap (NET) formation induced by phorbol 12-myristate 13-acetate (PMA; ) in primary human neutrophils when used at a concentration of 1 μM. LY333531 increases the mechanical nociceptive threshold in a rat model of diabetic hyperalgesia induced by streptozotocin (STZ; ).
The Uses of RUBOXISTAURIN HYDROCHLORIDE
A protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). It is used in treatment of diabetic microvascular comp
The Uses of RUBOXISTAURIN HYDROCHLORIDE
Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.
What are the applications of Application
LY-333,531 Hydrochloride is a selective PKC inhibitor with potential anticancer activity
Properties of RUBOXISTAURIN HYDROCHLORIDE
| alpha | D25 -28.7° (c = 1.0 in ethanol) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | orange-red |
Safety information for RUBOXISTAURIN HYDROCHLORIDE
Computed Descriptors for RUBOXISTAURIN HYDROCHLORIDE
New Products
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